seladelpar [Ligand Id: 11137] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL230158 (Mbx-8025, MBX-8025, RWJ-800025, Seladelpar) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869] | ||||||||
| ChEMBL | Agonist activity at PPARalpha (unknown origin) | B | 5.82 | pEC50 | 1500 | nM | EC50 | J Med Chem (2020) 63: 5031-5073 [PMID:31930920] |
| GtoPdb | Agonist activity determined by cell based transactivation assay. | - | 6 | pEC50 | >1000 | nM | EC50 | Bioorg Med Chem Lett (2007) 17: 3855-9 [PMID:17524639] |
| ChEMBL | Activity at human PPARalpha receptor by cell based transactivation assay | B | 6 | pEC50 | >1000 | nM | EC50 | Bioorg Med Chem Lett (2007) 17: 3855-3859 [PMID:17524639] |
| Peroxisome proliferator-activated receptor-β/δ/Peroxisome proliferator-activated receptor delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3979] [GtoPdb: 594] [UniProtKB: Q03181] | ||||||||
| ChEMBL | Agonist activity at PPARdelta (unknown origin) | B | 8.7 | pEC50 | 2 | nM | EC50 | J Med Chem (2020) 63: 5031-5073 [PMID:31930920] |
| ChEMBL | Agonist activity at PPARdelta (unknown origin) | B | 8.7 | pEC50 | 2 | nM | EC50 | Eur J Med Chem (2020) 197: 112311-112311 [PMID:32339855] |
| GtoPdb | Agonist activity determined by cell based transactivation assay. | - | 8.72 | pEC50 | 1.9 | nM | EC50 | Bioorg Med Chem Lett (2007) 17: 3855-9 [PMID:17524639] |
| ChEMBL | Agonist activity at human PPARdelta receptor by cell based transactivation assay | F | 8.72 | pEC50 | 1.9 | nM | EC50 | Bioorg Med Chem Lett (2007) 17: 3855-3859 [PMID:17524639] |
| Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] | ||||||||
| ChEMBL | Agonist activity at PPARgamma (unknown origin) | B | 5.3 | pEC50 | >5000 | nM | EC50 | J Med Chem (2020) 63: 5031-5073 [PMID:31930920] |
| GtoPdb | Agonist activity determined by cell based transactivation assay. | - | 6 | pEC50 | >1000 | nM | EC50 | Bioorg Med Chem Lett (2007) 17: 3855-9 [PMID:17524639] |
| ChEMBL | Activity at human PPARgamma receptor by cell based transactivation assay | B | 6 | pEC50 | >1000 | nM | EC50 | Bioorg Med Chem Lett (2007) 17: 3855-3859 [PMID:17524639] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
