ezutromid [Ligand Id: 11110] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1773683 (BMN 195, BMN-195, Ezutromid, Smt c1100, SMT-C1100, SMTC-1100)
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  • Aryl hydrocarbon receptor in Human [GtoPdb: 2951] [UniProtKB: P35869]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Utrophin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523230] [UniProtKB: P46939]
ChEMBL Modulation of human utrophinA expressed in mouse H2K cells assessed as upregulation of utrophin production after 24 hrs by luciferase reporter gene assay B 6.73 pEC50 187 nM EC50 J Med Chem (2020) 63: 7880-7891 [PMID:32551645]
Aryl hydrocarbon receptor in Human [GtoPdb: 2951] [UniProtKB: P35869]
GtoPdb apparent binding affinity determined using affinity‐based protein profiling (AfBPP), in a cellular context. - 7.3 pKd 50 nM Kd Angew Chem Int Ed Engl (2020) 59: 2420-2428 [PMID:31755636]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]