NBI-35965 [Ligand Id: 11025] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL380800 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CRF1 receptor/Corticotropin releasing factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1800] [GtoPdb: 212] [UniProtKB: P34998] | ||||||||
| ChEMBL | Binding affinity for human corticotropin releasing factor receptor 1 expressed in LtK- cells using [125I]sauvagine | B | 8.5 | pKi | 3.16 | nM | Ki | J Med Chem (2005) 48: 5780-5793 [PMID:16134945] |
| ChEMBL | In vitro inhibition of CRF-stimulated cAMP production in cell membranes expressing human CRF1 receptor | F | 7.1 | pIC50 | 79.43 | nM | IC50 | J Med Chem (2005) 48: 5780-5793 [PMID:16134945] |
| CRF1 receptor in Rat [GtoPdb: 212] [UniProtKB: P35353] | ||||||||
| GtoPdb | - | - | 8.4 | pKi | 4 | nM | Ki | Brain Res (2003) 985: 32-42 [PMID:12957366] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
