tenofovir [Ligand Id: 10948] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL483 (Atripla, GS-1275, PMP-A, Tenofovir, Truvada)
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  • Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL247] [UniProtKB: Q72547]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Core antigen in Hepatitis B virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075091] [UniProtKB: Q03732]
ChEMBL Inhibition of hepatitis B virus capsid assembly infected in human HepG2.215 cells assessed as reduction in viral DNA replication measured on day 7 by real time PCR analysis B 6.62 pEC50 241.5 nM EC50 Bioorg Med Chem (2017) 25: 1042-1056 [PMID:28082068]
Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547]
ChEMBL Binding affinity to ternary complex of HIV1 reverse transcriptase with primer/template in presence of dCTP substrate B 5.49 pKd 3200 nM Kd Antimicrob Agents Chemother (2007) 51: 2911-2919 [PMID:17517852]
ChEMBL Inhibition of HIV1 reverse transcriptase B 6.42 pIC50 380 nM IC50 Bioorg Med Chem (2007) 15: 5519-5528 [PMID:17562366]
ChEMBL Inhibition of wild type HIV 3B reverse transcriptase in MT2 cells B 6.42 pIC50 380 nM IC50 Bioorg Med Chem Lett (2008) 18: 1120-1123 [PMID:18164198]
ChEMBL Inhibition on HIV1 reverse transcriptase p66/p51 B 6.42 pIC50 380 nM IC50 Bioorg Med Chem (2009) 17: 1739-1746 [PMID:19179082]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]