PSB-1584 [Ligand Id: 10717] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL124977 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| GPR84/G-protein coupled receptor 84 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3714079] [GtoPdb: 120] [UniProtKB: Q9NQS5] | ||||||||
| ChEMBL | Displacement of [3H]PSB-1584 from recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 measured after 6 hrs by scintillation counting method | B | 8.53 | pKi | 2.98 | nM | Ki | J Med Chem (2020) 63: 2391-2410 [PMID:31721581] |
| GtoPdb | Potency in a cAMP assay. | - | 8.3 | pEC50 | 5 | nM | EC50 | ACS Omega (2018) 3: 3365-3383 [PMID:30023867] |
| ChEMBL | Agonist activity at recombinant human GPR84 expressed in CHO cells co-expressing beta-galactosidase/beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation measured after 15 mins by radioactive assay | F | 8.31 | pEC50 | 4.93 | nM | EC50 | J Med Chem (2020) 63: 2391-2410 [PMID:31721581] |
| GtoPdb | Potency in a β-arrestin recruitment assay. | - | 8.49 | pEC50 | 3.2 | nM | EC50 | ACS Omega (2018) 3: 3365-3383 [PMID:30023867] |
| ChEMBL | Agonist activity at recombinant human GPR84 expressed in CHO cells assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay | B | 8.5 | pEC50 | 3.18 | nM | EC50 | J Med Chem (2020) 63: 2391-2410 [PMID:31721581] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
