lorpucitinib [Ligand Id: 10631] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Janus kinase 1 in Human [GtoPdb: 2047] [UniProtKB: P23458] | ||||||||
| GtoPdb | Determined in a biochemical high-throughput mass spectrometry (HTMS) assay. | - | 9.4 | pIC50 | 0.4 | nM | IC50 | WO2018112379A1. Small molecule inhibitors of the JAK family of kinases (2018) |
| Janus kinase 2 in Human [GtoPdb: 2048] [UniProtKB: O60674] | ||||||||
| GtoPdb | Determined in a biochemical high-throughput mass spectrometry (HTMS) assay. | - | 8.07 | pIC50 | 8.6 | nM | IC50 | WO2018112379A1. Small molecule inhibitors of the JAK family of kinases (2018) |
| Janus kinase 3 in Human [GtoPdb: 2049] [UniProtKB: P52333] | ||||||||
| GtoPdb | Determined in a biochemical high-throughput mass spectrometry (HTMS) assay. | - | 7.04 | pIC50 | 92.2 | nM | IC50 | WO2018112379A1. Small molecule inhibitors of the JAK family of kinases (2018) |
| tyrosine kinase 2 in Human [GtoPdb: 2269] [UniProtKB: P29597] | ||||||||
| GtoPdb | Determined in a biochemical high-throughput mass spectrometry (HTMS) assay. | - | 8.13 | pIC50 | 7.4 | nM | IC50 | WO2018112379A1. Small molecule inhibitors of the JAK family of kinases (2018) |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
