WEHI-842 [Ligand Id: 10616] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3782104
  • Plasmodium falciparum plasmepsin V in Plasmodium falciparum [GtoPdb: 3106]
  • Plasmodium falciparum plasmepsin V in Plasmodium falciparum NF54 [GtoPdb: 3106]
  • Plasmodium falciparum plasmepsin V/Plasmepsin V in Plasmodium falciparum 3D7 [ChEMBL: CHEMBL3559649] [GtoPdb: 3106] [UniProtKB: Q8I6Z5]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum plasmepsin V in Plasmodium falciparum [GtoPdb: 3106]
GtoPdb - - 9.7 pIC50 0.2 nM IC50 Nat Struct Mol Biol (2015) 22: 590-6 [PMID:26214367]
Plasmodium falciparum plasmepsin V in Plasmodium falciparum NF54 [GtoPdb: 3106]
GtoPdb Parasite gametocyte assay - 7.4 pEC50 40 nM EC50 Cell Rep (2019) 29: 3796-3806.e4 [PMID:31851913]
Plasmodium falciparum plasmepsin V/Plasmepsin V in Plasmodium falciparum 3D7 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3559649] [GtoPdb: 3106] [UniProtKB: Q8I6Z5]
ChEMBL Inhibition of recombinant Plasmodium falciparum Plasmepsin 5 B 9.7 pIC50 0.2 nM IC50 J Med Chem (2020) 63: 4445-4467 [PMID:31913032]
GtoPdb Parasite growth inhibition assay - 6.4 pEC50 400 nM EC50 Nat Struct Mol Biol (2015) 22: 590-6 [PMID:26214367]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]