ChEMBL ligand: CHEMBL1085588
pyruvate kinase M1/2/Pyruvate kinase PKM in Human [ChEMBL: CHEMBL1075189] [GtoPdb: 3006] [UniProtKB: P14618] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
pyruvate kinase M1/2/Pyruvate kinase PKM in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075189] [GtoPdb: 3006] [UniProtKB: P14618]
ChEMBL	Activation of recombinant human PKM2 expressed in Escherichia coli BL21 at 4 uM incubated for 50 mins measured over 40 mins	B	7.04	pEC50	92	nM	EC50	J Med Chem (2018) 61: 4155-4164 [PMID:29641204]
ChEMBL	Activation of human recombinant full length His-tagged PKM2 (Asp354, Lys311, Glu397, Gly315 residues)	B	7.04	pEC50	92	nM	EC50	J Med Chem (2022) 65: 1171-1205 [PMID:34726055]
ChEMBL	Activation of PKM2 (unknown origin)	B	7.05	pEC50	90	nM	EC50	J Med Chem (2024) 67: 3339-3357 [PMID:38408027]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]