compound 18e [PMID: 31670517] [Ligand Id: 10549] activity data from GtoPdb

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  • fms related receptor tyrosine kinase 3 in Human [GtoPdb: 1807] [UniProtKB: P36888]
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  • Janus kinase 1 in Human [GtoPdb: 2047] [UniProtKB: P23458]
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  • Janus kinase 2 in Human [GtoPdb: 2048] [UniProtKB: O60674]
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  • Janus kinase 3 in Human [GtoPdb: 2049] [UniProtKB: P52333]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
fms related receptor tyrosine kinase 3 in Human [GtoPdb: 1807] [UniProtKB: P36888]
GtoPdb - - 8.4 pIC50 4 nM IC50 J Med Chem (2019) 62: 10305-10320 [PMID:31670517]
Janus kinase 1 in Human [GtoPdb: 2047] [UniProtKB: P23458]
GtoPdb - - 7.59 pIC50 26 nM IC50 J Med Chem (2019) 62: 10305-10320 [PMID:31670517]
Janus kinase 2 in Human [GtoPdb: 2048] [UniProtKB: O60674]
GtoPdb - - 9.15 pIC50 0.7 nM IC50 J Med Chem (2019) 62: 10305-10320 [PMID:31670517]
Janus kinase 3 in Human [GtoPdb: 2049] [UniProtKB: P52333]
GtoPdb - - 7.41 pIC50 39 nM IC50 J Med Chem (2019) 62: 10305-10320 [PMID:31670517]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.