compound 32 [PMID: 31638797] [Ligand Id: 10528] activity data from GtoPdb

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  • RAR-related orphan receptor-γ in Human [GtoPdb: 600] [UniProtKB: P51449]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
RAR-related orphan receptor-γ in Human [GtoPdb: 600] [UniProtKB: P51449]
GtoPdb Determined in a competition binding scintillation proximity assay (SPA), using recombinant His-tagged RORγ ligand binding domain (A262-S507) and [3H] 25-hydroxycholesterol as tracer. - 10.44 pIC50 0.04 nM IC50 WO2016179460A1. Tricyclic sulfones as rorĪ’ modulators (2016)
GtoPdb Determined in a luciferase reporter assay; measuring inhibition of constitutive activity of RORγt in Jurkat cells overexpressing full length RORγt proteins fused with the Gal4 Luc reporter. - 7.62 pEC50 24 nM EC50 J Med Chem (2019) 62: 9931-9946 [PMID:31638797]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.