avadomide [Ligand Id: 10522] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3989934 (Avadomide, CC122, CC-122)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cereblon/Protein cereblon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3763008] [GtoPdb: 3086] [UniProtKB: Q96SW2]
ChEMBL Binding affinity to human CRBN-thalidomide binding domain expressed in Escherichia coli by measuring baseline corrected normalized fluorescence by MST based assay B 4.78 pKi 16700 nM Ki ACS Med Chem Lett (2021) 12: 74-81 [PMID:33488967]
ChEMBL Binding affinity to human CRBN-thalidomide binding domain expressed in Escherichia coli by measuring baseline corrected normalized fluorescence by MST based assay B 4.41 pIC50 38700 nM IC50 ACS Med Chem Lett (2021) 12: 74-81 [PMID:33488967]
GtoPdb Inhibition of LPS-induced IL-1β production by human peripheral blood mononuclear cells. - 7.27 pIC50 54 nM IC50 WO2014039960A1. Methods for the treatment of locally advanced breast cancer (2014);
Blood (2015) 126: 779-89 [PMID:26002965]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]