compound 8 [PMID: 25898023] [Ligand Id: 10498] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3426624 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464] | ||||||||
| GtoPdb | Measured in a commercial radiometric kinase inhibition assay. | - | 9 | pIC50 | <1 | nM | IC50 | J Med Chem (2015) 58: 4309-24 [PMID:25898023] |
| ChEMBL | Inhibition of human N-terminal GST-tagged ROCK1 expressed in insect cells using long S6 kinase peptide as substrate by radiometric assay in presence of [32P]ATP | B | 9 | pIC50 | <1 | nM | IC50 | J Med Chem (2015) 58: 4309-4324 [PMID:25898023] |
| Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116] | ||||||||
| ChEMBL | Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infected insect cells using long S6 kinase peptide as substrate by radiometric assay in presence of [32P]ATP and 200 uM ATP | B | 8.39 | pIC50 | 4.1 | nM | IC50 | J Med Chem (2015) 58: 4309-4324 [PMID:25898023] |
| GtoPdb | Measured in a commercial radiometric kinase inhibition assay. | - | 9 | pIC50 | <1 | nM | IC50 | J Med Chem (2015) 58: 4309-24 [PMID:25898023] |
| ChEMBL | Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infected insect cells using long S6 kinase peptide as substrate by radiometric assay in presence of [32P]ATP | B | 9 | pIC50 | <1 | nM | IC50 | J Med Chem (2015) 58: 4309-4324 [PMID:25898023] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
