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ChEMBL ligand: CHEMBL3426624 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464] | ||||||||
GtoPdb | Measured in a commercial radiometric kinase inhibition assay. | - | 9 | pIC50 | <1 | nM | IC50 | J Med Chem (2015) 58: 4309-24 [PMID:25898023] |
ChEMBL | Inhibition of human N-terminal GST-tagged ROCK1 expressed in insect cells using long S6 kinase peptide as substrate by radiometric assay in presence of [32P]ATP | B | 9 | pIC50 | <1 | nM | IC50 | J. Med. Chem. (2015) 58: 4309-4324 [PMID:25898023] |
Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116] | ||||||||
ChEMBL | Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infected insect cells using long S6 kinase peptide as substrate by radiometric assay in presence of [32P]ATP and 200 uM ATP | B | 8.39 | pIC50 | 4.1 | nM | IC50 | J. Med. Chem. (2015) 58: 4309-4324 [PMID:25898023] |
GtoPdb | Measured in a commercial radiometric kinase inhibition assay. | - | 9 | pIC50 | <1 | nM | IC50 | J Med Chem (2015) 58: 4309-24 [PMID:25898023] |
ChEMBL | Inhibition of human N-terminal GST-tagged ROCK2 expressed in baculovirus-infected insect cells using long S6 kinase peptide as substrate by radiometric assay in presence of [32P]ATP | B | 9 | pIC50 | <1 | nM | IC50 | J. Med. Chem. (2015) 58: 4309-4324 [PMID:25898023] |
ChEMBL data shown on this page come from version 28:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]