AZD9898 [Ligand Id: 10479] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3961833 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Leukotriene C4 synthase in Human [GtoPdb: 1391] [UniProtKB: Q16873] | ||||||||
| GtoPdb | IC50 vs human recombinant purified LTC4 synthase determined by determination of inhibition of LTC4 methyl ester product formation in vitro | - | 9.54 | pIC50 | 0.29 | nM | IC50 |
WO2016177845. Cyclopropane carboxylic acid derivatives and pharmaceutical uses thereof (2016); J Med Chem (2019) 62: 7769-7787 [PMID:31415176] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
