deucravacitinib [Ligand Id: 10432] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| bone morphogenetic protein receptor type 2 in Human [GtoPdb: 1794] [UniProtKB: Q13873] | ||||||||
| GtoPdb | - | - | 6.71 | pIC50 | 193 | nM | IC50 | J Med Chem (2019) 62: 8973-8995 [PMID:31318208] |
| Janus kinase 1 in Human [GtoPdb: 2047] [UniProtKB: P23458] | ||||||||
| GtoPdb | Binding to JAK1 JH2 pseudokinase domain. | - | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (2019) 62: 8973-8995 [PMID:31318208] |
| tyrosine kinase 2 in Human [GtoPdb: 2269] [UniProtKB: P29597] | ||||||||
| GtoPdb | Determined in a Morrison titration by varying the concentration of the fluorescent probe in the TYK2 JH2 assay. | - | 10.7 | pKi | 0.02 | nM | Ki | J Med Chem (2019) 62: 8973-8995 [PMID:31318208] |
| GtoPdb | Binding to TYK2's JH2 pseudokinase domain in a biochemical binding assay. | - | 9.7 | pIC50 | 0.2 | nM | IC50 | J Med Chem (2019) 62: 8973-8995 [PMID:31318208] |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
