ONO-2333MS [Ligand Id: 10376] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1819077 (Ono-2333ms) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CRF1 receptor/Corticotropin releasing factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1800] [GtoPdb: 212] [UniProtKB: P34998] | ||||||||
| ChEMBL | Displacement of [125I]CRF from human corticotropin-releasing factor receptor 1 expressed in CHO-K1 cells after 2 hrs by gamma counting | B | 8.4 | pIC50 | 4 | nM | IC50 | Bioorg Med Chem (2011) 19: 5432-5445 [PMID:21865047] |
| GtoPdb | - | - | 8.4 | pIC50 | 4 | nM | IC50 | Bioorg Med Chem (2011) 19: 5432-45 [PMID:21865047] |
| ChEMBL | Antagonist activity at human corticotropin-releasing factor receptor 1 expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP production after 15 mins by enzyme immunoassay | F | 7.4 | pEC50 | 40 | nM | EC50 | Bioorg Med Chem (2011) 19: 5432-5445 [PMID:21865047] |
| CRF1 receptor/Corticotropin releasing factor receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4649] [GtoPdb: 212] [UniProtKB: P35353] | ||||||||
| ChEMBL | Displacement of [125I]CRF from corticotropin-releasing factor receptor 1 in rat brain membranes after 2 hrs by gamma counting | B | 8.15 | pIC50 | 7 | nM | IC50 | Bioorg Med Chem (2011) 19: 5432-5445 [PMID:21865047] |
| ChEMBL | Antagonist activity at rat corticotropin-releasing factor receptor 1 expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP production after 15 mins by enzyme immunoassay | F | 7.4 | pEC50 | 40 | nM | EC50 | Bioorg Med Chem (2011) 19: 5432-5445 [PMID:21865047] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
