tomivosertib [Ligand Id: 10167] activity data from GtoPdb

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  • CDC like kinase 4 in Human [GtoPdb: 1993] [UniProtKB: Q9HAZ1]
Created with Highcharts 10.3.3ValuesChart context menuCDC like kinase 4pKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
  • MAPK interacting serine/threonine kinase 1 in Human [GtoPdb: 2104] [UniProtKB: Q9BUB5]
Created with Highcharts 10.3.3ValuesChart context menuMAPK interacting serine/threonine kinase 1pKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • MAPK interacting serine/threonine kinase 2 in Human [GtoPdb: 2105] [UniProtKB: Q9HBH9]
Created with Highcharts 10.3.3ValuesChart context menuMAPK interacting serine/threonine kinase 2pKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • serine/threonine kinase 17a in Human [GtoPdb: 2214] [UniProtKB: Q9UEE5]
Created with Highcharts 10.3.3ValuesChart context menuserine/threonine kinase 17apKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CDC like kinase 4 in Human [GtoPdb: 1993] [UniProtKB: Q9HAZ1]
GtoPdb Biochemical inhibition assay. - 6.1 pIC50 790 nM IC50 J Med Chem (2018) 61: 3516-3540 [PMID:29526098]
MAPK interacting serine/threonine kinase 1 in Human [GtoPdb: 2104] [UniProtKB: Q9BUB5]
GtoPdb Biochemical inhibition assay. - 8.62 pIC50 2.4 nM IC50 J Med Chem (2018) 61: 3516-3540 [PMID:29526098]
MAPK interacting serine/threonine kinase 2 in Human [GtoPdb: 2105] [UniProtKB: Q9HBH9]
GtoPdb Biochemical inhibition assay. - 9 pIC50 1 nM IC50 J Med Chem (2018) 61: 3516-3540 [PMID:29526098]
serine/threonine kinase 17a in Human [GtoPdb: 2214] [UniProtKB: Q9UEE5]
GtoPdb Biochemical inhibition assay. - 6.89 pIC50 130 nM IC50 J Med Chem (2018) 61: 3516-3540 [PMID:29526098]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.