JAK3 inhibitor 34 [Ligand Id: 10157] activity data from GtoPdb

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  • Janus kinase 1 in Human [GtoPdb: 2047] [UniProtKB: P23458]
  • This target only has 0 pki data point
  • 0
1 _lig_chart_1 Janus kinase 1 Human
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  • Janus kinase 2 in Human [GtoPdb: 2048] [UniProtKB: O60674]
  • This target only has 0 pki data point
  • 0
2 _lig_chart_2 Janus kinase 2 Human
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  • Janus kinase 3 in Human [GtoPdb: 2049] [UniProtKB: P52333]
  • This target only has 0 pki data point
  • 0
3 _lig_chart_3 Janus kinase 3 Human
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  • tyrosine kinase 2 in Human [GtoPdb: 2269] [UniProtKB: P29597]
  • This target only has 0 pki data point
  • 0
4 _lig_chart_4 tyrosine kinase 2 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Janus kinase 1 in Human [GtoPdb: 2047] [UniProtKB: P23458]
GtoPdb - - 5.48 pIC50 3345 nM IC50 J Med Chem (2018) 61: 10665-10699 [PMID:30423248]
Janus kinase 2 in Human [GtoPdb: 2048] [UniProtKB: O60674]
GtoPdb - - 5.18 pIC50 >6578 nM IC50 J Med Chem (2018) 61: 10665-10699 [PMID:30423248]
Janus kinase 3 in Human [GtoPdb: 2049] [UniProtKB: P52333]
GtoPdb - - 7.31 pIC50 49 nM IC50 J Med Chem (2018) 61: 10665-10699 [PMID:30423248]
tyrosine kinase 2 in Human [GtoPdb: 2269] [UniProtKB: P29597]
GtoPdb - - 5 pIC50 >10000 nM IC50 J Med Chem (2018) 61: 10665-10699 [PMID:30423248]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.