PQR620 [Ligand Id: 10142] activity data from GtoPdb

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  • mechanistic target of rapamycin kinase in Human [GtoPdb: 2109] [UniProtKB: P42345]
Created with Highcharts 10.3.3ValuesChart context menumechanistic target of rapamycin kinasepKd HumanpKi HumanpIC50 HumanpEC50 Human024681012Highcharts.com
  • phosphatidylinositol 3-kinase catalytic subunit type 3 in Human [GtoPdb: 2152] [UniProtKB: Q8NEB9]
Created with Highcharts 10.3.3ValuesChart context menuphosphatidylinositol 3-kinase catalytic subunit type 3pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha in Human [GtoPdb: 2153] [UniProtKB: P42336]
Created with Highcharts 10.3.3ValuesChart context menuphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphapKd HumanpKi HumanpIC50 HumanpEC50 Human01234567Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mechanistic target of rapamycin kinase in Human [GtoPdb: 2109] [UniProtKB: P42345]
GtoPdb Binding affinity constant. - 9.57 pKd 0.27 nM Kd J Med Chem (2018) 61: 10084-10105 [PMID:30359003]
GtoPdb In vitro inhibition constant. - 7.97 pKi 10.8 nM Ki J Med Chem (2018) 61: 10084-10105 [PMID:30359003]
phosphatidylinositol 3-kinase catalytic subunit type 3 in Human [GtoPdb: 2152] [UniProtKB: Q8NEB9]
GtoPdb - - 5.56 pKd 2750 nM Kd J Med Chem (2018) 61: 10084-10105 [PMID:30359003]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha in Human [GtoPdb: 2153] [UniProtKB: P42336]
GtoPdb - - 6 pKd 1000 nM Kd J Med Chem (2018) 61: 10084-10105 [PMID:30359003]
GtoPdb - - 5.38 pKi 4203 nM Ki J Med Chem (2018) 61: 10084-10105 [PMID:30359003]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.