dual sEH/FAAH inhibitor 11 [Ligand Id: 10124] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Fatty acid amide hydrolase in Human [GtoPdb: 1400] [UniProtKB: O00519] | ||||||||
| GtoPdb | - | - | 7.43 | pKi | 37 | nM | Ki | ACS Omega (2018) 3: 14076-14086 [PMID:30411058] |
| GtoPdb | - | - | 8.1 | pIC50 | 8 | nM | IC50 | WO2017160861A1. Inhibitors for soluble epoxide hydrolase (seh) and fatty acid amide hydrolase (faah) (2017) |
| Fatty acid amide hydrolase in Mouse [GtoPdb: 1400] [UniProtKB: O08914] | ||||||||
| GtoPdb | - | - | 5.85 | pIC50 | 1400 | nM | IC50 | ACS Omega (2018) 3: 14076-14086 [PMID:30411058] |
| Fatty acid amide hydrolase in Rat [GtoPdb: 1400] [UniProtKB: P97612] | ||||||||
| GtoPdb | Following a 60 min preincubation with inhibitor. | - | 6.52 | pIC50 | 300 | nM | IC50 | ACS Omega (2018) 3: 14076-14086 [PMID:30411058] |
| epoxide hydrolase 2 in Human [GtoPdb: 2970] [UniProtKB: P34913] | ||||||||
| GtoPdb | - | - | 8.3 | pIC50 | 5 | nM | IC50 | WO2017160861A1. Inhibitors for soluble epoxide hydrolase (seh) and fatty acid amide hydrolase (faah) (2017) |
| epoxide hydrolase 2 in Mouse [GtoPdb: 2970] [UniProtKB: P34914] | ||||||||
| GtoPdb | - | - | 7.57 | pIC50 | 27 | nM | IC50 | ACS Omega (2018) 3: 14076-14086 [PMID:30411058] |
| epoxide hydrolase 2 in Rat [GtoPdb: 2970] [UniProtKB: P80299] | ||||||||
| GtoPdb | - | - | 7.74 | pIC50 | 18 | nM | IC50 | ACS Omega (2018) 3: 14076-14086 [PMID:30411058] |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
