RORC2 inverse agonist 66 [PMID: 30130103] [Ligand Id: 10078] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| RAR-related orphan receptor-γ in Human [GtoPdb: 600] [UniProtKB: P51449] | ||||||||
| GtoPdb | In a TR-FRET assay measuring agonist-=induced inhibition of co-activator peptide recruitment to RORC2 ligand binding domain. | - | 7.78 | pIC50 | 16.6 | nM | IC50 | WO2016046755A1. Methyl-and trifluoromethyl-substituted pyrrolopyridine modulators of rorc2 and methods of use thereof (2016) |
| GtoPdb | In a TR-FRET assay measuring agonist-induced inhibition of co-factor recruitment to RORC2 ligand binding domain. | - | 8.39 | pIC50 | 4.1 | nM | IC50 | J Med Chem (2018) 61: 10415-10439 [PMID:30130103] |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
