ERW1041E [Ligand Id: 10048] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL219514 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| transglutaminase 2/Protein-glutamine gamma-glutamyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2730] [GtoPdb: 3015] [UniProtKB: P21980] | ||||||||
| ChEMBL | Inhibition of human recombinant TG2 expressed in Escherichia coli | B | 4.96 | pKi | 11000 | nM | Ki | J Med Chem (2006) 49: 7493-7501 [PMID:17149878] |
| GtoPdb | Inhibition of enzyme activity in vitro. | - | 5.8 | pIC50 | 1600 | nM | IC50 | PLoS ONE (2018) 13: e0196433 [PMID:29689097] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
