Signal regulatory proteins
Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Overview
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More detailed introduction 
Signal-regulatory proteins (SIRP) are membrane proteins that are mainly expressed by myeloid cells. SIPRs play essential roles in immune cell and immune response regulation, whilst minimising damage to self [1].
Targets
Targets of relevance to immunopharmacology are highlighted in blue
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SIRPA (CD172a)
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How to cite this family page
Database page citation:
Signal regulatory proteins. Accessed on 03/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=989.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.
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