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Protein phosphatases act as functional antagonists of kinases to regulate reversible protein phosphorylation, which is the dominant post-translational modification for modulating cellular signalling. Balance between kinase and phosphatase activities is crucial for regulating diverse cellular functions (including proliferation, differentiation, and stress responses) and physiological processes, whilst mutation, overexpression, or deletion of genes for the proteins on either side of this balance results in abnormal cellular responses, with often pathological effects.


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Database page citation:

Phosphatases. Accessed on 19/05/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.