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Janus kinase (JakA) family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Janus kinases (JAKs) are a family of four enzymes; JAK1, JAK2, JAK3 and tyrosine kinase 2 (TYK2). They are essential for cytokine signalling and are strongly linked to both cancer and inflammatory diseases.


Targets of relevance to immunopharmacology are highlighted in blue

JAK1 (Janus kinase 1) C Show summary » More detailed page

JAK2 (Janus kinase 2) C Show summary » More detailed page

JAK3 (Janus kinase 3) C Show summary » More detailed page

Tyk2 (tyrosine kinase 2) C Show summary » More detailed page


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How to cite this family page

Database page citation:

Janus kinase (JakA) family. Accessed on 16/07/2020. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.