Janus kinases (JAKs) are a family of four enzymes; JAK1, JAK2, JAK3 and tyrosine kinase 2 (TYK2). They are essential for cytokine signalling and are strongly linked to both cancer and inflammatory diseases.

* Key recommended reading is highlighted with an asterisk

* Bharadwaj U, Kasembeli MM, Robinson P, Tweardy DJ. (2020) Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution. Pharmacol Rev, 72 (2): 486-526. [PMID:32198236]

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