Top ▲

Prostanoid receptors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Click here for help

« Hide More detailed introduction go icon to follow link

Prostanoid receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Prostanoid Receptors [74]) are activated by the endogenous ligands prostaglandins PGD2, PGE1, PGE2 , PGF, PGH2, prostacyclin [PGI2] and thromboxane A2. Differences and similarities between human and rodent prostanoid receptor orthologues, and their specific roles in pathophysiologic conditions are reviewed in [42]. Measurement of the potency of PGI2 and thromboxane A2 is hampered by their instability in physiological salt solution; they are often replaced by cicaprost and U46619, respectively, in receptor characterization studies.

Receptors

Click here for help

Targets of relevance to immunopharmacology are highlighted in blue

DP1 receptor C Show summary » More detailed page go icon to follow link

DP2 receptor C Show summary » More detailed page go icon to follow link

EP1 receptor C Show summary » More detailed page go icon to follow link

EP2 receptor C Show summary » More detailed page go icon to follow link

EP3 receptor C Show summary » More detailed page go icon to follow link

EP4 receptor C Show summary » More detailed page go icon to follow link

FP receptor C Show summary » More detailed page go icon to follow link

IP receptor C Show summary » More detailed page go icon to follow link

TP receptor C Show summary » More detailed page go icon to follow link

Comments

Click here for help

Show »

Further reading

Click here for help

Show »

References

Click here for help

Show »

NC-IUPHAR subcommittee and family contributors

Show »

How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: G protein-coupled receptors. Br J Pharmacol. 176 Issue S1: S21-S141.