Death-associated kinase (DAPK) family
Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Overview
Death-associated kinases (DAPKs) are tumour suppressor genes [1]. Family members share homologous catalytic domains and cell death-associated functions. DAPK activity is required for cell death induced by death receptor signalling, cytokines, matrix detachment, and oncogene-induced hyperproliferation. Loss of DAPK function is identified in many cancers.
Enzymes
Targets of relevance to immunopharmacology are highlighted in blue
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DAPK1 (death associated protein kinase 1)
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DAPK2 (death associated protein kinase 2)
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DAPK3 (death associated protein kinase 3)
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DRAK1 (serine/threonine kinase 17a)
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DRAK2 (serine/threonine kinase 17b)
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How to cite this family page
Database page citation:
Death-associated kinase (DAPK) family. Accessed on 20/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=572.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.
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