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serine/threonine kinase 17b

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Target not currently curated in GtoImmuPdb

Target id: 2215

Nomenclature: serine/threonine kinase 17b

Abbreviated Name: DRAK2

Family: Death-associated kinase (DAPK) family

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 372 2q32.3 STK17B serine/threonine kinase 17b
Mouse - 372 1 C1.1 Stk17b serine/threonine kinase 17b (apoptosis-inducing)
Rat - 371 9q31 Stk17b serine/threonine kinase 17b
Previous and Unofficial Names Click here for help
DAP kinase-related apoptosis-inducing protein kinase 2 | death-associated protein kinase-related 2
Database Links Click here for help
Alphafold O94768 (Hs), Q8BG48 (Mm), Q91XS8 (Rn)
BRENDA 2.7.11.1
ChEMBL Target CHEMBL3980 (Hs)
Ensembl Gene ENSG00000081320 (Hs), ENSMUSG00000026094 (Mm), ENSRNOG00000012502 (Rn)
Entrez Gene 9262 (Hs), 98267 (Mm), 170904 (Rn)
Human Protein Atlas ENSG00000081320 (Hs)
KEGG Enzyme 2.7.11.1
KEGG Gene hsa:9262 (Hs), mmu:98267 (Mm), rno:170904 (Rn)
OMIM 604727 (Hs)
Pharos O94768 (Hs)
RefSeq Nucleotide NM_004226 (Hs), NM_133810 (Mm), NM_133392 (Rn)
RefSeq Protein NP_004217 (Hs), NP_598571 (Mm), NP_596883 (Rn)
UniProtKB O94768 (Hs), Q8BG48 (Mm), Q91XS8 (Rn)
Wikipedia STK17B (Hs)
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of human serine/threonine kinase 17B (STK17B).
PDB Id:  3LM0
Resolution:  2.35Å
Species:  Human
References: 
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of human serine/threonine kinase 17B (STK17B) in complex with quercetin .
PDB Id:  3LM5
Ligand:  quercetin
Resolution:  2.29Å
Species:  Human
References: 
Enzyme Reaction Click here for help
EC Number: 2.7.11.1
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2
Key to terms and symbols Click column headers to sort
Target used in screen: DRAK2
Ligand Sp. Type Action Value Parameter
KW-2449 Small molecule or natural product Hs Inhibitor Inhibition 8.3 pKd
lestaurtinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 8.3 pKd
MLN-8054 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 8.1 pKd
tamatinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 8.0 pKd
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.7 pKd
fedratinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 7.3 pKd
sunitinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 7.0 pKd
SU-14813 Small molecule or natural product Hs Inhibitor Inhibition 6.5 pKd
neratinib Small molecule or natural product Approved drug Hs Inhibitor Inhibition 6.0 pKd
dovitinib Small molecule or natural product Hs Inhibitor Inhibition 5.7 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]

How to cite this page

Death-associated kinase (DAPK) family: serine/threonine kinase 17b. Last modified on 26/03/2013. Accessed on 24/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2215.