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Rho kinase C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Rho kinase (also known as P160ROCK, Rho-activated kinase) is activated by members of the Rho small G protein family, which are activated by GTP exchange factors, such as ARHGEF1 (Q92888, p115-RhoGEF), which in turn may be activated by Gα12/13 subunits [4].


Targets of relevance to immunopharmacology are highlighted in blue

Rho kinase 1 (Rho associated coiled-coil containing protein kinase 1 / ROCK1) C Show summary » More detailed page

Rho kinase 2 (Rho associated coiled-coil containing protein kinase 2 / ROCK2) C Show summary » More detailed page

Further reading

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How to cite this family page

Database page citation:

Rho kinase. Accessed on 08/07/2020. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.