Orphan or poorly characterized SLC22 family members

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SLC superfamily of solute carriers
SLC22 family of organic cation and anion transporters
Orphan or poorly characterized SLC22 family members

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Transporters

Targets of relevance to immunopharmacology are highlighted in blue

OAT10 (Organic anion transporter 10 / SLC22A13) Show summary »« Hide summary

Target Id	1032
Nomenclature	Organic anion transporter 10
Systematic nomenclature	SLC22A13
Common abbreviation	OAT10
Previous and unofficial names	OCTL1 \| OCTL3 \| ORCTL3 \| organic cationic transporter-like 3 \| solute carrier family 22 (organic anion transporter), member 13 \| solute carrier family 22 (organic anion/urate transporter), member 13 \| solute carrier family 22 (organic cation transporter)
Genes	SLC22A13 (Hs), Slc22a13 (Mm), Slc22a13 (Rn)
Ensembl ID	ENSG00000172940 (Hs), ENSMUSG00000074028 (Mm), ENSRNOG00000056476 (Rn)
UniProtKB AC	Q9Y226 (Hs), Q6A4L0 (Mm)
Bioparadigms SLC Tables	SLC22A13 (Hs)
RESOLUTE	SLC22A13 (Hs)

OCTL2 (Organic cation transporter-like 2 / SLC22A14) Show summary »« Hide summary

Target Id

1033

Nomenclature

Organic cation transporter-like 2

Systematic nomenclature

SLC22A14

Common abbreviation

OCTL2

Previous and unofficial names

ORCTL4 | solute carrier family 22 | solute carrier family 22 (organic cation transporter) | solute carrier family 22 (organic cation transporter), member 14

Genes

SLC22A14 (Hs), Slc22a14 (Mm), Slc22a14 (Rn)

Ensembl ID

ENSG00000144671 (Hs), ENSMUSG00000070280 (Mm), ENSRNOG00000042259 (Rn)

UniProtKB AC

Q9Y267 (Hs)

Bioparadigms SLC Tables

SLC22A14 (Hs)

RESOLUTE

SLC22A14 (Hs)

Substrates

riboflavin [1]

FLIPT1 (Fly-like putative transporter 1 / SLC22A15) Show summary »« Hide summary

Target Id

1034

Nomenclature

Fly-like putative transporter 1

Systematic nomenclature

SLC22A15

Common abbreviation

FLIPT1

Previous and unofficial names

solute carrier family 22 (organic cation transporter), member 15 | solute carrier family 22 | solute carrier family 22 (organic anion/cation transporter), member 15 | solute carrier family 22 (organic anion/cation transporter)

Genes

SLC22A15 (Hs), Slc22a15 (Mm), Slc22a15 (Rn)

Ensembl ID

ENSG00000163393 (Hs), ENSMUSG00000033147 (Mm), ENSRNOG00000033051 (Rn)

UniProtKB AC

Q8IZD6 (Hs), Q504N2 (Mm)

Bioparadigms SLC Tables

SLC22A15 (Hs)

RESOLUTE

SLC22A15 (Hs)

Substrates

creatine [2]

betaine [2]

carnosine [2]

MPP⁺ [2]

L-carnitine [2]

ergothioneine [2]

BOIT (Brain-type organic cation transporter / SLC22A17) Show summary »« Hide summary

Target Id	1035
Nomenclature	Brain-type organic cation transporter
Systematic nomenclature	SLC22A17
Common abbreviation	BOIT
Previous and unofficial names	BOCT \| NGALR \| neutrophil gelatinase-associated lipocalin receptor \| brain-specific organic ion transporter \| lipocalin-2 receptor \| solute carrier family 22 (organic cation transporter), member 17 \| solute carrier family 22 \| solute carrier family 22 (organic cation transporter)
Genes	SLC22A17 (Hs), Slc22a17 (Mm), Slc22a17 (Rn)
Ensembl ID	ENSG00000092096 (Hs), ENSMUSG00000022199 (Mm), ENSRNOG00000016414 (Rn)
UniProtKB AC	Q8WUG5 (Hs), Q9D9E0 (Mm), Q9P290 (Rn)
Bioparadigms SLC Tables	SLC22A17 (Hs)
RESOLUTE	SLC22A17 (Hs)

OAT5 (Organic anion transporter 5 / SLC22A10) C Show summary »« Hide summary

Target Id

1029

Nomenclature

Organic anion transporter 5

Systematic nomenclature

SLC22A10

Common abbreviation

OAT5

Previous and unofficial names

solute carrier family 22 (organic anion/cation transporter), member 10 | solute carrier family 22, member 10

Genes

SLC22A10 (Hs)

Ensembl ID

ENSG00000184999 (Hs)

UniProtKB AC

Q63ZE4 (Hs)

Bioparadigms SLC Tables

SLC22A10 (Hs)

RESOLUTE

SLC22A10 (Hs)

Substrates

ochratoxin A [4]

Stoichiometry

Unknown

ORCTL2 (Organic cation transporter-like 2 / SLC22A18) Show summary »« Hide summary

Target Id	1036
Nomenclature	Organic cation transporter-like 2
Systematic nomenclature	SLC22A18
Common abbreviation	ORCTL2
Previous and unofficial names	Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein \| Imprinted multi-membrane spanning polyspecific transporter-related protein 1 \| tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein \| BWSCR1A \| IMPT1 \| SLC22A1L \| TSSC5 \| solute carrier family 22 (organic cation transporter), member 18 \| solute carrier family 22 \| solute carrier family 22 (organic cation transporter)
Genes	SLC22A18 (Hs), Slc22a18 (Mm), Slc22a18 (Rn)
Ensembl ID	ENSG00000110628 (Hs), ENSMUSG00000000154 (Mm), ENSRNOG00000020562 (Rn)
UniProtKB AC	Q96BI1 (Hs), Q78KK3 (Mm), Q6AY78 (Rn)
Bioparadigms SLC Tables	SLC22A18 (Hs)
RESOLUTE	SLC22A18 (Hs)

OAT6 / SLC22A20 Show summary »« Hide summary

Target Id	1037
Nomenclature	OAT6
Systematic nomenclature	SLC22A20
Previous and unofficial names	solute carrier family 22 (organic anion transporter), member 20 \| solute carrier family 22, member 20 \| solute carrier family 22 \| SLC22A20 \| solute carrier family 22 (organic anion transporter)
Genes	SLC22A20P (Hs), Slc22a20 (Mm), Slc22a20 (Rn)
Ensembl ID	ENSG00000197847 (Hs), ENSMUSG00000037451 (Mm), ENSRNOG00000022673 (Rn)
UniProtKB AC	A6NK97 (Hs), Q80UJ1 (Mm)
Bioparadigms SLC Tables	SLC22A20 (Hs)

SLC22A23 Show summary »« Hide summary

SLC22A24 Show summary »« Hide summary

UST6 / SLC22A25 Show summary »« Hide summary

Target Id	1040
Nomenclature	UST6
Systematic nomenclature	SLC22A25
Previous and unofficial names	HIMTP \| Oat5 \| organic anion transporter 5 \| Slc22a19 \| solute carrier family 22 (organic anion transporter), member 19 \| solute carrier family 22 (organic anion/cation transporter), member 9 \| solute carrier family 22 member 10 \| solute carrier family 22, member 25 \| solute carrier family 22, member 24 \| solute carrier family 22 \| solute carrier family 22 (organic anion transporter) \| Slc22a24
Genes	SLC22A25 (Hs), Slc22a19 (Mm), Slc22a19 (Rn)
Ensembl ID	ENSG00000196600 (Hs), ENSMUSG00000024757 (Mm), ENSRNOG00000056396 (Rn)
UniProtKB AC	Q6T423 (Hs)
Bioparadigms SLC Tables	SLC22A25 (Hs)
RESOLUTE	SLC22A25 (Hs)

solute carrier family 22 member 31 / SLC22A31 Show summary »« Hide summary

Target Id	2557
Nomenclature	solute carrier family 22 member 31
Systematic nomenclature	SLC22A31
Previous and unofficial names	solute carrier family 22, member 31
Genes	SLC22A31 (Hs)
Ensembl ID	ENSG00000259803 (Hs)
UniProtKB AC	A6NKX4 (Hs)
Bioparadigms SLC Tables	SLC22A31 (Hs)
RESOLUTE	SLC22A31 (Hs)

References

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1. Kuang W, Zhang J, Lan Z, Deepak RNVK, Liu C, Ma Z, Cheng L, Zhao X, Meng X, Wang W et al.. (2021) SLC22A14 is a mitochondrial riboflavin transporter required for sperm oxidative phosphorylation and male fertility. Cell Rep, 35 (3): 109025. [PMID:33882315]

2. Yee SW, Buitrago D, Stecula A, Ngo HX, Chien HC, Zou L, Koleske ML, Giacomini KM. (2020) Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies. FASEB J, 34 (12): 15734-15752. [PMID:33124720]

3. Yee SW, Stecula A, Chien HC, Zou L, Feofanova EV, van Borselen M, Cheung KWK, Yousri NA, Suhre K, Kinchen JM et al.. (2019) Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies. PLoS Genet, 15 (9): e1008208. [PMID:31553721]

4. Youngblood GL, Sweet DH. (2004) Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney. Am J Physiol Renal Physiol, 287 (2): F236-44. [PMID:15068970]

NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.