Top ▲

SLC12 family of cation-coupled chloride transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


Click here for help

« Hide

The SLC12 family of chloride transporters contribute to ion fluxes across a variety of tissues, particularly in the kidney and choroid plexus of the brain. Within this family, further subfamilies are identifiable: NKCC1, NKCC2 and NCC constitute a group of therapeutically-relevant transporters, targets for loop and thiazide diuretics. These 12 TM proteins exhibit cytoplasmic termini and an extended extracellular loop at TM7/8 and are kidney-specific (NKCC2 and NCC) or show a more widespread distribution (NKCC1). A second family, the K-Cl co-transporters are also 12 TM domain proteins with cytoplasmic termini, but with an extended extracellular loop at TM 5/6. CCC6 exhibits structural similarities with the K-Cl co-transporters, while CCC9 is divergent, with 11 TM domains and a cytoplasmic N-terminus and extracellular C-terminus.


Click here for help

Targets of relevance to immunopharmacology are highlighted in blue

NKCC2 (Kidney-specific Na-K-Cl symporter / SLC12A1) C Show summary » More detailed page go icon to follow link

NKCC1 (Basolateral Na-K-Cl symporter / SLC12A2) C Show summary »

Target Id 969
Nomenclature Basolateral Na-K-Cl symporter
Systematic nomenclature SLC12A2
Common abbreviation NKCC1
Previous and unofficial names BSC1 | Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1 | BSC | BSC2 | solute carrier family 12 (sodium/potassium/chloride transporters), member 2 | sy-ns | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | solute carrier family 12
Genes SLC12A2 (Hs), Slc12a2 (Mm), Slc12a2 (Rn)
Ensembl ID ENSG00000064651 (Hs), ENSMUSG00000024597 (Mm), ENSRNOG00000015971 (Rn)
UniProtKB AC P55011 (Hs), P55012 (Mm)
Bioparadigms SLC Tables SLC12A2 (Hs)
piretanide pIC50 5.6 [3]
bumetanide pIC50 5.6 [3]
furosemide pIC50 5.1 [3]
Stoichiometry 1 Na+ : 1 K+ : 2 Cl- (in)

NCC (Na-Cl symporter / SLC12A3) C Show summary » More detailed page go icon to follow link

KCC1 (K-Cl cotransporter 1 / SLC12A4) C Show summary »

KCC2 (K-Cl cotransporter 2 / SLC12A5) C Show summary »

KCC3 (K-Cl cotransporter 3 / SLC12A6) C Show summary »

KCC4 (K-Cl cotransporter 4 / SLC12A7) C Show summary »

CCC9 (Cation-chloride cotransporter 9 / SLC12A8) C Show summary »

CCC6 (Cation-chloride cotransporter 6 / SLC12A9) Show summary »


Click here for help

Show »

Further reading

Click here for help

Show »


Click here for help

Show »

How to cite this family page

Database page citation:

SLC12 family of cation-coupled chloride transporters. Accessed on 20/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.