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SLC12 family of cation-coupled chloride transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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The SLC12 family of chloride transporters contribute to ion fluxes across a variety of tissues, particularly in the kidney and choroid plexus of the brain. Within this family, further subfamilies are identifiable: NKCC1, NKCC2 and NCC constitute a group of therapeutically-relevant transporters, targets for loop and thiazide diuretics. These 12 TM proteins exhibit cytoplasmic termini and an extended extracellular loop at TM7/8 and are kidney-specific (NKCC2 and NCC) or show a more widespread distribution (NKCC1). A second family, the K-Cl co-transporters are also 12 TM domain proteins with cytoplasmic termini, but with an extended extracellular loop at TM 5/6. CCC6 exhibits structural similarities with the K-Cl co-transporters, while CCC9 is divergent, with 11 TM domains and a cytoplasmic N-terminus and extracellular C-terminus.


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Targets of relevance to immunopharmacology are highlighted in blue

NKCC2 (Kidney-specific Na-K-Cl symporter / SLC12A1) C Show summary » More detailed page go icon to follow link

NKCC1 (Basolateral Na-K-Cl symporter / SLC12A2) C Show summary »

NCC (Na-Cl symporter / SLC12A3) C Show summary » More detailed page go icon to follow link

KCC1 (K-Cl cotransporter 1 / SLC12A4) C Show summary »

KCC2 (K-Cl cotransporter 2 / SLC12A5) C Show summary »

KCC3 (K-Cl cotransporter 3 / SLC12A6) C Show summary »

KCC4 (K-Cl cotransporter 4 / SLC12A7) C Show summary »

CCC9 (Cation-chloride cotransporter 9 / SLC12A8) C Show summary »

CCC6 (Cation-chloride cotransporter 6 / SLC12A9) Show summary »


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Further reading

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How to cite this family page

Database page citation:

SLC12 family of cation-coupled chloride transporters. Accessed on 13/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.