Class C Orphans | G protein-coupled receptors | IUPHAR/BPS Guide to IMMUNOPHARMACOLOGY

GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

Class C Orphans C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Show »« Hide More detailed introduction go icon to follow link

This set contains class C 'orphan' G protein coupled receptors where the endogenous ligand(s) is not known.

Receptors

Targets of relevance to immunopharmacology are highlighted in blue

GPR156 C Show summary »« Hide summary More detailed page go icon to follow link

GPR158 C Show summary »« Hide summary More detailed page go icon to follow link

GPR179 C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	211
Nomenclature	GPR179
Previous and unofficial names	GPR158-like 1
Genes	GPR179 (Hs), Gpr179 (Mm), Gpr179 (Rn)
Ensembl ID	ENSG00000277399 (Hs), ENSMUSG00000070337 (Mm), ENSRNOG00000029245 (Rn)
UniProtKB AC	Q6PRD1 (Hs)
Principal transduction	-
Comment	Forms a complex with the extracellular matrix protein pikachurin (EGFLAM ; Q63HQ2) in retinal photoreceptor synapses [1].

GPRC5A C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	258
Nomenclature	GPRC5A
Previous and unofficial names	RAIG1 \| retinoic acid induced 3 \| orphan G protein-coupling receptor PEIG-1 \| retinoic acid-induced gene 1 protein \| Retinoic acid-induced protein 3 \| GPCR5A \| RAI3 \| G protein-coupled receptor, class C, group 5, member A \| G protein-coupled receptor
Genes	GPRC5A (Hs), Gprc5a (Mm), Gprc5a (Rn)
Ensembl ID	ENSG00000013588 (Hs), ENSMUSG00000046733 (Mm), ENSRNOG00000008412 (Rn)
UniProtKB AC	Q8NFJ5 (Hs), Q8BHL4 (Mm)
Principal transduction	-

GPRC5B C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	259
Nomenclature	GPRC5B
Previous and unofficial names	RAIG₂ \| retinoic acid-induced gene 2 protein \| G protein-coupled receptor, class C, group 5, member B \| G protein-coupled receptor
Genes	GPRC5B (Hs), Gprc5b (Mm), Gprc5b (Rn)
Ensembl ID	ENSG00000167191 (Hs), ENSMUSG00000008734 (Mm), ENSRNOG00000016013 (Rn)
UniProtKB AC	Q9NZH0 (Hs), Q923Z0 (Mm)
Principal transduction	-

GPRC5C C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	260
Nomenclature	GPRC5C
Previous and unofficial names	RAIG₃ \| retinoic acid-induced gene 3 protein \| G protein-coupled receptor, family C, group 5, member C \| G protein-coupled receptor, class C, group 5, member C \| G protein-coupled receptor
Genes	GPRC5C (Hs), Gprc5c (Mm), Gprc5c (Rn)
Ensembl ID	ENSG00000170412 (Hs), ENSMUSG00000051043 (Mm), ENSRNOG00000003144 (Rn)
UniProtKB AC	Q9NQ84 (Hs), Q8K3J9 (Mm), Q3KRC4 (Rn)
Principal transduction	-

GPRC5D C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	261
Nomenclature	GPRC5D
Previous and unofficial names	RAIG₄ \| G protein-coupled receptor, class C, group 5, member D \| G protein-coupled receptor
Genes	GPRC5D (Hs), Gprc5d (Mm), Gprc5d (Rn)
Ensembl ID	ENSG00000111291 (Hs), ENSMUSG00000030205 (Mm), ENSRNOG00000008439 (Rn)
UniProtKB AC	Q9NZD1 (Hs), Q9JIL6 (Mm)
Principal transduction	-

GPRC6 receptor C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	55
Nomenclature	GPRC6 receptor
Previous and unofficial names	GPCR6A \| G protein-coupled receptor, family C, group 6, member A \| G protein-coupled receptor, class C, group 6, member A \| G protein-coupled receptor
Genes	GPRC6A (Hs), Gprc6a (Mm), Gprc6a (Rn)
Ensembl ID	ENSG00000173612 (Hs), ENSMUSG00000019905 (Mm), ENSRNOG00000000401 (Rn)
UniProtKB AC	Q5T6X5 (Hs), Q8K4Z6 (Mm), Q70VB1 (Rn)
Principal transduction	G_q/G₁₁ family
Comment	GPRC6 is a related G_q-coupled receptor which responds to basic amino acids [2].

References

Show »« Hide

NC-IUPHAR subcommittee and family contributors

Show »« Hide

Subcommittee members:

Hans Bräuner-Osborne (Chairperson-GPRC5)
Professor, DSc, PhD
Head of Section for Experimental Pharmacology
Department of Drug Design and Pharmacology
Faculty of Health and Medical Sciences
University of Copenhagen
Universitetsparken 2
2100 Copenhagen
Denmark

Other contributors:

Daniel Bikle
Endocrinology University of California School of Medicine
San Francisco
CA
94121-1598
USA

Edward M. Brown
Division of Endocrinology, Diabetes and hypertension
Brigham and Women’s Hospital
221 Longwood Ave.
EBRC223
Boston
MA
02115
USA

Arthur Conigrave
School of Molecular and Microbial Biosciences
University of Sydney
Maze Crescent
NSW 02121
Australia

Dolores Shoback
Endocrine Research Unit (111N)
San Francisco
CA
94121
USA

How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors. Br J Pharmacol. 180 Suppl 2:S23-S144.