Gene and Protein Information
class C G protein-coupled receptor
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	357	12p13.1	GPRC5A	G protein-coupled receptor class C group 5 member A	2
Mouse	7	356	6 G1	Gprc5a	G protein-coupled receptor, family C, group 5, member A
Rat	7	358	4q43	Gprc5a	G protein-coupled receptor, class C, group 5, member A

Previous and Unofficial Names

RAIG1 | retinoic acid induced 3 | orphan G protein-coupling receptor PEIG-1 | retinoic acid-induced gene 1 protein | Retinoic acid-induced protein 3 | GPCR5A | RAI3 | G protein-coupled receptor, class C, group 5, member A | G protein-coupled receptor

Database Links
Alphafold	Q8NFJ5 (Hs), Q8BHL4 (Mm)
ChEMBL Target	CHEMBL4523896 (Hs)
Ensembl Gene	ENSG00000013588 (Hs), ENSMUSG00000046733 (Mm), ENSRNOG00000008412 (Rn)
Entrez Gene	9052 (Hs), 232431 (Mm), 312790 (Rn)
Human Protein Atlas	ENSG00000013588 (Hs)
KEGG Gene	hsa:9052 (Hs), mmu:232431 (Mm), rno:312790 (Rn)
OMIM	604138 (Hs)
Pharos	Q8NFJ5 (Hs)
RefSeq Nucleotide	NM_003979 (Hs), NM_181444 (Mm), NM_001079890 (Rn)
RefSeq Protein	NP_003970 (Hs), NP_852109 (Mm), NP_001073359 (Rn)
UniProtKB	Q8NFJ5 (Hs), Q8BHL4 (Mm)
Wikipedia	GPRC5A (Hs)

Tissue Distribution
High expression in adult lung tissue. Low to moderate expression in adult placenta, kidney, prostate, testis, ovary, small intestine and colon. Not detectable in adult heart, brain, liver, skeletal muscle, pancreas, spleen, thymus and leukocyte. Species:  Human Technique:  Northern blotting. References:  2
High expression in adult lung tissue. Medium expression in adult kidnet and colon. Low expression in adult heart, pancreas, placenta, ovary, prostate, small intestine and testis. Not detectable in adult brain, liver, skeletal muscle, peripheral leukocyte, spleen and thymus. Species:  Human Technique:  RT-PCR References:  1

Expression Datasets
Show »« Hide Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website] There should be a chart of expression data here, you may need to enable JavaScript!

Physiological Consequences of Altering Gene Expression
RAIG1 receptor knockout mice exhibit normal lung development, despite high expression of the gene in the wild-type lung. Species:  Mouse Tissue:  Technique:  Gene targeting in embryonic stem cells. References:  3

Phenotypes, Alleles and Disease Models

Mouse data from MGI

Show »« Hide Allele Composition & genetic background Accession Phenotype Id Phenotype Reference Gprc5atm1Rlo Gprc5atm1Rlo/Gprc5atm1Rlo involves: 129 * C57BL/6 MGI:1891250  MP:0002048 increased lung adenoma incidence PMID: 18000218  Gprc5atm1Rlo Gprc5atm1Rlo/Gprc5atm1Rlo involves: 129 * C57BL/6 MGI:1891250  MP:0008014 increased lung tumor incidence PMID: 18000218  Gprc5a+|Gprc5atm1Rlo Gprc5atm1Rlo/Gprc5a+ involves: 129 * C57BL/6 MGI:1891250  MP:0008014 increased lung tumor incidence PMID: 18000218  Gprc5atm1Rlo Gprc5atm1Rlo/Gprc5atm1Rlo involves: 129 * C57BL/6 MGI:1891250  MP:0002027 lung adenocarcinoma PMID: 18000218  Gprc5atm1Rlo Gprc5atm1Rlo/Gprc5atm1Rlo involves: 129 * C57BL/6 MGI:1891250  MP:0001861 lung inflammation PMID: 18000218  Gprc5atm1Jsx Gprc5atm1Jsx/Gprc5atm1Jsx involves: 129X1/SvJ MGI:1891250  MP:0002169 no abnormal phenotype detected PMID: 15677768

General Comments
GPRC5A mRNA expression is induced by retinoic acid in some cell lines [4].