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Alanine/serine/cysteine transporter subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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ASC transporters mediate Na+-dependent exchange of small neutral amino acids such as Ala, Ser, Cys and Thr and their structure is predicted to be similar to that of the glutamate transporters [1,9]. ASCT1 and ASCT2 also exhibit thermodynamically uncoupled chloride channel activity associated with substrate transport [3,10]. Whereas EAATs counter-transport K+ (see above) ASCTs do not and their function is independent of the intracellular concentration of K+ [10].

Transporters

Targets of relevance to immunopharmacology are highlighted in blue

ASCT1 (Alanine/serine/cysteine transporter 1 / SLC1A4) C Show summary »

ASCT2 (Alanine/serine/cysteine transporter 2 / SLC1A5) C Show summary » More detailed page

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.