The SLC1 family of sodium dependent transporters includes the plasma membrane located glutamate transporters and the neutral amino acid transporters ASCT1 and ASCT2 [1-5].

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* Key recommended reading is highlighted with an asterisk

* Beart PM, O'Shea RD. (2007) Transporters for L-glutamate: an update on their molecular pharmacology and pathological involvement. Br J Pharmacol, 150 (1): 5-17. [PMID:17088867]

* Bjørn-Yoshimoto WE, Underhill SM. (2016) The importance of the excitatory amino acid transporter 3 (EAAT3). Neurochem Int, 98: 4-18. [PMID:27233497]

Bridges RJ, Esslinger CS. (2005) The excitatory amino acid transporters: pharmacological insights on substrate and inhibitor specificity of the EAAT subtypes. Pharmacol Ther, 107 (3): 271-85. [PMID:16112332]

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Bunch L, Erichsen MN, Jensen AA. (2009) Excitatory amino acid transporters as potential drug targets. Expert Opin Ther Targets, 13 (6): 719-31. [PMID:19456273]

Chao XD, Fei F, Fei Z. (2010) The role of excitatory amino acid transporters in cerebral ischemia. Neurochem Res, 35 (8): 1224-30. [PMID:20440555]

Danbolt NC. (2001) Glutamate uptake. Prog Neurobiol, 65 (1): 1-105. [PMID:11369436]

Dunlop J. (2006) Glutamate-based therapeutic approaches: targeting the glutamate transport system. Curr Opin Pharmacol, 6 (1): 103-7. [PMID:16368269]

Dunlop J, Butera JA. (2006) Ligands targeting the excitatory amino acid transporters (EAATs). Curr Top Med Chem, 6 (17): 1897-906. [PMID:17017964]

* Fahlke C, Kortzak D, Machtens JP. (2016) Molecular physiology of EAAT anion channels. Pflugers Arch, 468 (3): 491-502. [PMID:26687113]

* Fontana AC. (2015) Current approaches to enhance glutamate transporter function and expression. J Neurochem, 134 (6): 982-1007. [PMID:26096891]

* Freidman N, Chen I, Wu Q, Briot C, Holst J, Font J, Vandenberg R, Ryan R. (2020) Amino Acid Transporters and Exchangers from the SLC1A Family: Structure, Mechanism and Roles in Physiology and Cancer. Neurochem Res, 45 (6): 1268-1286. [PMID:31981058]

Fuchs BC, Bode BP. (2005) Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime?. Semin Cancer Biol, 15 (4): 254-66. [PMID:15916903]

* Grewer C, Gameiro A, Rauen T. (2014) SLC1 glutamate transporters. Pflugers Arch, 466 (1): 3-24. [PMID:24240778]

Grewer C, Gameiro A, Zhang Z, Tao Z, Braams S, Rauen T. (2008) Glutamate forward and reverse transport: from molecular mechanism to transporter-mediated release after ischemia. IUBMB Life, 60 (9): 609-19. [PMID:18543277]

Grewer C, Rauen T. (2005) Electrogenic glutamate transporters in the CNS: molecular mechanism, pre-steady-state kinetics, and their impact on synaptic signaling. J Membr Biol, 203 (1): 1-20. [PMID:15834685]

Hinoi E, Takarada T, Tsuchihashi Y, Yoneda Y. (2005) Glutamate transporters as drug targets. Curr Drug Targets CNS Neurol Disord, 4 (2): 211-20. [PMID:15857305]

Huang YH, Bergles DE. (2004) Glutamate transporters bring competition to the synapse. Curr Opin Neurobiol, 14 (3): 346-52. [PMID:15194115]

* Jensen AA, Fahlke C, Bjørn-Yoshimoto WE, Bunch L. (2015) Excitatory amino acid transporters: recent insights into molecular mechanisms, novel modes of modulation and new therapeutic possibilities. Curr Opin Pharmacol, 20: 116-23. [PMID:25466154]

Jiang J, Amara SG. (2011) New views of glutamate transporter structure and function: advances and challenges. Neuropharmacology, 60 (1): 172-81. [PMID:20708631]

* Kanai Y, Clémençon B, Simonin A, Leuenberger M, Lochner M, Weisstanner M, Hediger MA. (2013) The SLC1 high-affinity glutamate and neutral amino acid transporter family. Mol Aspects Med, 34 (2-3): 108-20. [PMID:23506861]

Kanner BI. (2006) Structure and function of sodium-coupled GABA and glutamate transporters. J Membr Biol, 213 (2): 89-100. [PMID:17417704]

Kanner BI, Zomot E. (2008) Sodium-coupled neurotransmitter transporters. Chem Rev, 108 (5): 1654-68. [PMID:18393466]

Kim K, Lee SG, Kegelman TP, Su ZZ, Das SK, Dash R, Dasgupta S, Barral PM, Hedvat M, Diaz P et al.. (2011) Role of excitatory amino acid transporter-2 (EAAT2) and glutamate in neurodegeneration: opportunities for developing novel therapeutics. J Cell Physiol, 226 (10): 2484-93. [PMID:21792905]

Lee A, Pow DV. (2010) Astrocytes: Glutamate transport and alternate splicing of transporters. Int J Biochem Cell Biol, 42 (12): 1901-6. [PMID:20883814]

McGivan JD, Bungard CI. (2007) The transport of glutamine into mammalian cells. Front Biosci, 12: 874-82. [PMID:17127344]

Palacín M, Estévez R, Bertran J, Zorzano A. (1998) Molecular biology of mammalian plasma membrane amino acid transporters. Physiol Rev, 78 (4): 969-1054. [PMID:9790568]

Ryan RM, Vandenberg RJ. (2005) A channel in a transporter. Clin Exp Pharmacol Physiol, 32 (1-2): 1-6. [PMID:15730426]

Sheldon AL, Robinson MB. (2007) The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention. Neurochem Int, 51 (6-7): 333-55. [PMID:17517448]

Shigeri Y, Seal RP, Shimamoto K. (2004) Molecular pharmacology of glutamate transporters, EAATs and VGLUTs. Brain Res Brain Res Rev, 45 (3): 250-65. [PMID:15210307]

Shimamoto K. (2008) Glutamate transporter blockers for elucidation of the function of excitatory neurotransmission systems. Chem Rec, 8 (3): 182-99. [PMID:18563834]

Sonders MS, Quick M, Javitch JA. (2005) How did the neurotransmitter cross the bilayer? A closer view. Curr Opin Neurobiol, 15 (3): 296-304. [PMID:15919190]

* Takahashi K, Foster JB, Lin CL. (2015) Glutamate transporter EAAT2: regulation, function, and potential as a therapeutic target for neurological and psychiatric disease. Cell Mol Life Sci, 72 (18): 3489-506. [PMID:26033496]

Tzingounis AV, Wadiche JI. (2007) Glutamate transporters: confining runaway excitation by shaping synaptic transmission. Nat Rev Neurosci, 8 (12): 935-47. [PMID:17987031]

Vandenberg RJ. (2006) Mutational analysis of glutamate transporters. Handb Exp Pharmacol, (175): 113-35. [PMID:16722233]

Vandenberg RJ, Huang S, Ryan RM. (2008) Slips, leaks and channels in glutamate transporters. Channels (Austin), 2 (1): 51-8. [PMID:18690049]

Vandenberg RJ, Ju P, Aubrey KR, Ryan RM, Mitrovic AD. (2004) Allosteric modulation of neurotransmitter transporters at excitatory synapses. Eur J Pharm Sci, 23 (1): 1-11. [PMID:15324920]

Vandenberg RJ, Ryan RM. (2005) How and why are channels in transporters?. Sci STKE, 2005 (280): pe17. [PMID:15840837]

1. Amara SG, Arriza JL. (1993) Neurotransmitter transporters: three distinct gene families. Curr Opin Neurobiol, 3 (3): 337-44. [PMID:8103691]

2. Beart PM, O'Shea RD. (2007) Transporters for L-glutamate: an update on their molecular pharmacology and pathological involvement. Br J Pharmacol, 150 (1): 5-17. [PMID:17088867]

3. Kanai Y, Hediger MA. (2003) The glutamate and neutral amino acid transporter family: physiological and pharmacological implications. Eur J Pharmacol, 479 (1-3): 237-47. [PMID:14612154]

4. Kanai Y, Hediger MA. (2004) The glutamate/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects. Pflugers Arch, 447 (5): 469-79. [PMID:14530974]

5. Palacín M, Estévez R, Bertran J, Zorzano A. (1998) Molecular biology of mammalian plasma membrane amino acid transporters. Physiol Rev, 78 (4): 969-1054. [PMID:9790568]

Philip M. Beart Florey Institute of Neuroscience and Mental Health 30 Royal Parade Parkville 3052 Victoria Australia