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Na+/K+-ATPases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The cell-surface Na+/K+-ATPase is an integral membrane protein which regulates the membrane potential of the cell by maintaining gradients of Na+ and K+ ions across the plasma membrane, also making a small, direct contribution to membrane potential, particularly in cardiac cells. For every molecule of ATP hydrolysed, the Na+/K+-ATPase extrudes three Na+ ions and imports two K+ ions. The active transporter is a heteromultimer with incompletely defined stoichiometry, possibly as tetramers of heterodimers, each consisting of one of four large, ten TM domain catalytic α subunits and one of three smaller, single TM domain glycoprotein β-subunits (see table). Additional protein partners known as FXYD proteins (e.g. FXYD2, P54710) appear to associate with and regulate the activity of the pump.

Transporters

Targets of relevance to immunopharmacology are highlighted in blue

sodium/potassium-transporting ATPase subunit α-1 Show summary » More detailed page

sodium/potassium-transporting ATPase subunit α-2 Show summary »

sodium/potassium-transporting ATPase subunit α-3 Show summary »

sodium/potassium-transporting ATPase subunit α-4 Show summary »

sodium/potassium-transporting ATPase subunit β-1 Show summary »

sodium/potassium-transporting ATPase subunit β-2 Show summary »

sodium/potassium-transporting ATPase subunit β-3 Show summary »

sodium/potassium-transporting ATPase subunit γ Show summary » More detailed page

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How to cite this family page

Database page citation:

Na+/K+-ATPases. Accessed on 23/04/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=158.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Transporters. Br J Pharmacol. 174 Suppl 1: S360-S446.