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Robinow syndrome, autosomal recessive

Disease ID:832
Name:Robinow syndrome, autosomal recessive
Associated with:1 target
1 immuno-relevant ligand
Database Links
OMIM: 268310
Orphanet: ORPHA1507


receptor tyrosine kinase like orphan receptor 2


Key to terms and symbols Click ligand name to view ligand summary Click column headers to sort
Ligand References Clinical and Disease comments
Immuno Disease Comments: An approved gold-containing complex with antirheumatic activity.
Clinical Use: Auranofin is a gold-containing medicine used for the management of rheumatoid arthritis in patients who do not respond to or are intolerant of other medicines. | View clinical data
Bioactivity Comments: Auranofin inhibits thioredoxin reductase isolated from human placenta, with a Ki of 4nM [1]. | View biological activity


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1. Gromer S, Arscott LD, Williams Jr CH, Schirmer RH, Becker K. (1998) Human placenta thioredoxin reductase. Isolation of the selenoenzyme, steady state kinetics, and inhibition by therapeutic gold compounds. J Biol Chem, 273 (32): 20096-101. [PMID:9685351]