Peptide transporter 3 | SLC15 family of peptide transporters | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Peptide transporter 3

  Target has curated data in GtoImmuPdb

Target id: 986

Nomenclature: Peptide transporter 3

Abbreviated Name: PHT2

Systematic Nomenclature: SLC15A3

Family: SLC15 family of peptide transporters

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - SLC15A3 solute carrier family 15 member 3
Mouse - - Slc15a3 solute carrier family 15, member 3
Rat - - Slc15a3 solute carrier family 15 member 3
Previous and Unofficial Names
solute carrier family 15 | peptide/histidine transporter PHT2 | PTR3 | solute carrier family 15 member 3 | solute carrier family 15 (oligopeptide transporter), member 3
Database Links
Specialist databases
Bioparadigms SLC Tables SLC15A3 (Hs)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia
Substrates and Reaction Kinetics
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
muramyl dipeptide Hs - - 1,4
histidyl-leucine Hs - - 2
MDP-rhodamine Hs - - 1
Tri-DAP Hs - - 4
dipeptides Hs - -
protons Hs - -
tripeptides Hs - -
Stoichiometry
PHT2 has not been analyzed systematically with respect to driving force, mode of transport, and substrate specificity. The pH dependence observed for transport of histidine [2] and the model peptides used, i.e., carnosine [2] and histidyl-leucine [2], suggest a similar mode of operation as PEPT1 and PEPT2 proteins.
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Parameter Reference
[14C]histidine Hs - - - 2
[2]
[3H]histidine Hs - - - 2
[2]
Immunopharmacology Comments
SLC15A3 and SLC15A4 are preferentially expressed by cells within the lymphatic system, including dendritic cells. Expression of these two genes is upregulated in response to TLR stimulation [1,3]. There is some experimental evidence which suggests that SLC15A3 plays an important role in regulating TLR4-mediated inflammatory responses [3].
Cell Type Associations
Immuno Cell Type:  Dendritic cells
Cell Ontology Term:   dendritic cell (CL:0000451)
References:  1

References

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1. Nakamura N, Lill JR, Phung Q, Jiang Z, Bakalarski C, de Mazière A, Klumperman J, Schlatter M, Delamarre L, Mellman I. (2014) Endosomes are specialized platforms for bacterial sensing and NOD2 signalling. Nature, 509 (7499): 240-4. [PMID:24695226]

2. Sakata K, Yamashita T, Maeda M, Moriyama Y, Shimada S, Tohyama M. (2001) Cloning of a lymphatic peptide/histidine transporter. Biochem. J., 356 (Pt 1): 53-60. [PMID:11336635]

3. Song F, Yi Y, Li C, Hu Y, Wang J, Smith DE, Jiang H. (2018) Regulation and biological role of the peptide/histidine transporter SLC15A3 in Toll-like receptor-mediated inflammatory responses in macrophage. Cell Death Dis, 9 (7): 770. [PMID:29991810]

4. Wang Y, Hu Y, Li P, Weng Y, Kamada N, Jiang H, Smith DE. (2018) Expression and regulation of proton-coupled oligopeptide transporters in colonic tissue and immune cells of mice. Biochem. Pharmacol., 148: 163-173. [PMID:29305856]

Contributors

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How to cite this page

David T. Thwaites, Tiziano Verri.
SLC15 family of peptide transporters: Peptide transporter 3. Last modified on 15/02/2019. Accessed on 20/05/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=986.