Quaternary Structure: Complexes

ENaCαβγ

Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	2	640	16p12.2-p12.1	SCNN1B	sodium channel epithelial 1 subunit beta	1
Mouse	2	638	7 65.07 cM	Scnn1b	sodium channel, nonvoltage-gated 1 beta	1
Rat	2	638	1q36	Scnn1b	sodium channel epithelial 1 subunit beta	1

Previous and Unofficial Names

ENaCbeta | beta-ENaC | beta-NaCH | epithelial Na(+) channel subunit beta | RNENACB | SCNEB | ENaC beta | sodium channel, non-voltage-gated 1, beta subunit | sodium channel, non voltage gated 1 beta subunit | sodium channel | sodium channel epithelial 1 beta subunit

Database Links
Alphafold	P51168 (Hs), Q9WU38 (Mm), P37090 (Rn)
ChEMBL Target	CHEMBL1628483 (Hs)
DrugBank Target	P51168 (Hs)
Ensembl Gene	ENSG00000168447 (Hs), ENSMUSG00000030873 (Mm), ENSRNOG00000030981 (Rn)
Entrez Gene	6338 (Hs), 20277 (Mm), 24767 (Rn)
Human Protein Atlas	ENSG00000168447 (Hs)
KEGG Gene	hsa:6338 (Hs), mmu:20277 (Mm), rno:24767 (Rn)
OMIM	600760 (Hs)
Pharos	P51168 (Hs)
UniProtKB	P51168 (Hs), Q9WU38 (Mm), P37090 (Rn)
Wikipedia	SCNN1B (Hs)

Natural/Endogenous Ligands
sodium

Clinically-Relevant Mutations and Pathophysiology
Disease:  Bronchiectasis with or without elevated sweat chloride 1, BESC1 Synonyms: Bronchiectasis [Disease Ontology: DOID:9563] Idiopathic bronchiectasis [Orphanet: ORPHA60033] Disease Ontology: DOID:9563 OMIM: 211400 Orphanet: ORPHA60033
Disease:  Liddle syndrome; LIDLS Disease Ontology: DOID:0050477 OMIM: 177200 Orphanet: ORPHA526
Disease:  Pseudohypoaldosteronism, type I, autosomal recessive; PHA1B Synonyms: Autosomal recessive pseudohypoaldosteronism type 1 [Orphanet: ORPHA171876] Generalized pseudohypoaldosteronism type 1 [Orphanet: ORPHA171876] Pseudohypoaldosteronism [Disease Ontology: DOID:4479] Disease Ontology: DOID:4479 OMIM: 264350 Orphanet: ORPHA171876