Top ▲


  Target has curated data in GtoImmuPdb

Target id: 482

Nomenclature: P2X5

Family: P2X receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 2 422 17p13.3 P2RX5 purinergic receptor P2X 5 10
Mouse 2 455 11 B5 P2rx5 purinergic receptor P2X, ligand-gated ion channel, 5 7
Rat 2 455 10q24 P2rx5 purinergic receptor P2X 5 6
Gene and Protein Information Comments
Seventy-five P2X5 genes have been identified in the genomes of 75 placental mammalian species (Eutheria) [13].
Previous and Unofficial Names
P2X purinoceptor 5 | purinergic receptor P2X, ligand gated ion channel, 5 | purinergic receptor P2X
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Natural/Endogenous Ligands
Comments: Endogenous agonist: ATP at human [3] and mouse [7] P2X5 receptors.

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
ATP Rn Agonist 6.0 pEC50 8
pEC50 6.0 (EC50 1x10-6 M) [8]
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
suramin Rn Antagonist 5.4 pIC50 8
pIC50 5.4 (IC50 4x10-6 M) [8]
Immunopharmacology Comments
P2X ligand-gated ion channels elicit pro-inflammatory immune responses upon activation by extracellular ATP that acts as a DAMP when released from damaged or infected cells [4-5].
Cell Type Associations
Immuno Cell Type:  B cells
Cell Ontology Term:   B cell (CL:0000236)
Comment:  Human B cells express all P2 receptor subtypes.
References:  11
Immuno Cell Type:  T cells
Comment:  T cells express P2X receptors 1, 4 and 5. ATP-induced activation of these receptors in T cells is associated with proliferation, cytokine production and thymocyte apoptosis.
References:  5,12
Immuno Process Associations
Immuno Process:  Tissue repair
GO Annotations:  Associated to 1 GO processes
GO:0043416 regulation of skeletal muscle tissue regeneration ISO
Physiological Consequences of Altering Gene Expression
Altered inflammatory response in murine osteoclasts, with reduced bone loss.
Species:  Mouse
Tissue:  Osteoclasts
Technique:  Gene knockout
References:  9
General Comments
The human P2X5 subunit exists as 3 alternatively spliced isoforms (A, which is tabulated above; B, NP_778255 - 397 aa and C, NP_778256 - 178 aa).

Of all the functional P2X receptors, only P2X5 homopolymer is unregulated by intracellular PIPn [1-2].


Show »

1. Ase AR, Bernier LP, Blais D, Pankratov Y, Séguéla P. (2010) Modulation of heteromeric P2X1/5 receptors by phosphoinositides in astrocytes depends on the P2X1 subunit. J. Neurochem., 113 (6): 1676-84. [PMID:20374427]

2. Bernier LP, Ase AR, Séguéla P. (2013) Post-translational regulation of P2X receptor channels: modulation by phospholipids. Front Cell Neurosci, 7: 226. [PMID:24324400]

3. Bo X, Jiang LH, Wilson HL, Kim M, Burnstock G, Surprenant A, North RA. (2003) Pharmacological and biophysical properties of the human P2X5 receptor. Mol. Pharmacol., 63 (6): 1407-16. [PMID:12761352]

4. Burnstock G, Boeynaems JM. (2014) Purinergic signalling and immune cells. Purinergic Signal., 10 (4): 529-64. [PMID:25352330]

5. Cekic C, Linden J. (2016) Purinergic regulation of the immune system. Nat. Rev. Immunol., 16 (3): 177-92. [PMID:26922909]

6. Collo G, North RA, Kawashima E, Merlo-Pich E, Neidhart S, Surprenant A, Buell G. (1996) Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J. Neurosci., 16 (8): 2495-507. [PMID:8786426]

7. Cox JA, Barmina O, Voigt MM. (2001) Gene structure, chromosomal localization, cDNA cloning and expression of the mouse ATP-gated ionotropic receptor P2X5 subunit. Gene, 270 (1-2): 145-52. [PMID:11404011]

8. Jacobson KA, Jarvis MF, Williams M. (2002) Purine and pyrimidine (P2) receptors as drug targets. J. Med. Chem., 45 (19): 4057-93. [PMID:12213051]

9. Kim H, Walsh MC, Takegahara N, Middleton SA, Shin HI, Kim J, Choi Y. (2017) The purinergic receptor P2X5 regulates inflammasome activity and hyper-multinucleation of murine osteoclasts. Sci Rep, 7 (1): 196. [PMID:28298636]

10. Lê KT, Paquet M, Nouel D, Babinski K, Séguéla P. (1997) Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system. FEBS Lett., 418 (1-2): 195-9. [PMID:9414125]

11. Przybyła T, Sakowicz-Burkiewicz M, Pawełczyk T. (2018) Purinergic signaling in B cells. Acta Biochim. Pol., 65 (1): 1-7. [PMID:29360885]

12. Vaeth M, Feske S. (2018) Ion channelopathies of the immune system. Curr. Opin. Immunol., 52: 39-50. [PMID:29635109]

13. Zdobnov EM, Tegenfeldt F, Kuznetsov D, Waterhouse RM, Simão FA, Ioannidis P, Seppey M, Loetscher A, Kriventseva EV. (2017) OrthoDB v9.1: cataloging evolutionary and functional annotations for animal, fungal, plant, archaeal, bacterial and viral orthologs. Nucleic Acids Res., 45 (D1): D744-D749. [PMID:27899580]


Show »

How to cite this page

Select citation format: