P2X5
Target has curated data in GtoImmuPdb
Target id: 482
Nomenclature: P2X5
Family: P2X receptors
Annotation status:
Awaiting annotation/under development. Please contact us if you can help with annotation.
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Contents:
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 2 | 422 | 17p13.3 | P2RX5 | purinergic receptor P2X 5 | 10 |
| Mouse | 2 | 455 | 11 B5 | P2rx5 | purinergic receptor P2X, ligand-gated ion channel, 5 | 7 |
| Rat | 2 | 455 | 10q24 | P2rx5 | purinergic receptor P2X 5 | 6 |
| Gene and Protein Information Comments | ||||||
| Seventy-five P2X5 genes have been identified in the genomes of 75 placental mammalian species (Eutheria) [13]. | ||||||
| Previous and Unofficial Names |
| P2X purinoceptor 5 | purinergic receptor P2X, ligand gated ion channel, 5 | purinergic receptor P2X |
| Database Links |
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| CATH/Gene3D | 2.60.490.10 |
| ChEMBL Target | CHEMBL4942 (Hs), CHEMBL2495 (Rn) |
| Ensembl Gene | ENSG00000083454 (Hs), ENSMUSG00000005950 (Mm), ENSRNOG00000019208 (Rn) |
| Entrez Gene | 5026 (Hs), 94045 (Mm), 113995 (Rn) |
| Human Protein Atlas | ENSG00000083454 (Hs) |
| KEGG Gene | hsa:5026 (Hs), mmu:94045 (Mm), rno:113995 (Rn) |
| OMIM | 602836 (Hs) |
| RefSeq Nucleotide | NM_002561 (Hs), NM_033321 (Mm), NM_080780 (Rn) |
| RefSeq Protein | NP_002552 (Hs), NP_201578 (Mm), NP_542958 (Rn) |
| UniProtKB | Q93086 (Hs), Q3UYI1 (Mm), P51578 (Rn) |
| Wikipedia | P2RX5 (Hs) |
| Natural/Endogenous Ligands |
| ATP |
| Comments: Endogenous agonist: ATP at human [3] and mouse [7] P2X5 receptors. |
Download all structure-activity data for this target as a CSV file 
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| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||
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| Immunopharmacology Comments |
| P2X ligand-gated ion channels elicit pro-inflammatory immune responses upon activation by extracellular ATP that acts as a DAMP when released from damaged or infected cells [4-5]. |
| Cell Type Associations | ||||||||
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| Physiological Consequences of Altering Gene Expression
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| General Comments |
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The human P2X5 subunit exists as 3 alternatively spliced isoforms (A, which is tabulated above; B, NP_778255 - 397 aa and C, NP_778256 - 178 aa). Of all the functional P2X receptors, only P2X5 homopolymer is unregulated by intracellular PIPn [1-2]. |
References
1. Ase AR, Bernier LP, Blais D, Pankratov Y, Séguéla P. (2010) Modulation of heteromeric P2X1/5 receptors by phosphoinositides in astrocytes depends on the P2X1 subunit. J. Neurochem., 113 (6): 1676-84. [PMID:20374427]
2. Bernier LP, Ase AR, Séguéla P. (2013) Post-translational regulation of P2X receptor channels: modulation by phospholipids. Front Cell Neurosci, 7: 226. [PMID:24324400]
3. Bo X, Jiang LH, Wilson HL, Kim M, Burnstock G, Surprenant A, North RA. (2003) Pharmacological and biophysical properties of the human P2X5 receptor. Mol. Pharmacol., 63 (6): 1407-16. [PMID:12761352]
4. Burnstock G, Boeynaems JM. (2014) Purinergic signalling and immune cells. Purinergic Signal., 10 (4): 529-64. [PMID:25352330]
5. Cekic C, Linden J. (2016) Purinergic regulation of the immune system. Nat. Rev. Immunol., 16 (3): 177-92. [PMID:26922909]
6. Collo G, North RA, Kawashima E, Merlo-Pich E, Neidhart S, Surprenant A, Buell G. (1996) Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J. Neurosci., 16 (8): 2495-507. [PMID:8786426]
7. Cox JA, Barmina O, Voigt MM. (2001) Gene structure, chromosomal localization, cDNA cloning and expression of the mouse ATP-gated ionotropic receptor P2X5 subunit. Gene, 270 (1-2): 145-52. [PMID:11404011]
8. Jacobson KA, Jarvis MF, Williams M. (2002) Purine and pyrimidine (P2) receptors as drug targets. J. Med. Chem., 45 (19): 4057-93. [PMID:12213051]
9. Kim H, Walsh MC, Takegahara N, Middleton SA, Shin HI, Kim J, Choi Y. (2017) The purinergic receptor P2X5 regulates inflammasome activity and hyper-multinucleation of murine osteoclasts. Sci Rep, 7 (1): 196. [PMID:28298636]
10. Lê KT, Paquet M, Nouel D, Babinski K, Séguéla P. (1997) Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system. FEBS Lett., 418 (1-2): 195-9. [PMID:9414125]
11. Przybyła T, Sakowicz-Burkiewicz M, Pawełczyk T. (2018) Purinergic signaling in B cells. Acta Biochim. Pol., 65 (1): 1-7. [PMID:29360885]
12. Vaeth M, Feske S. (2018) Ion channelopathies of the immune system. Curr. Opin. Immunol., 52: 39-50. [PMID:29635109]
13. Zdobnov EM, Tegenfeldt F, Kuznetsov D, Waterhouse RM, Simão FA, Ioannidis P, Seppey M, Loetscher A, Kriventseva EV. (2017) OrthoDB v9.1: cataloging evolutionary and functional annotations for animal, fungal, plant, archaeal, bacterial and viral orthologs. Nucleic Acids Res., 45 (D1): D744-D749. [PMID:27899580]
How to cite this page
Francesco Di Virgilio, Richard J. Evans, Simonetta Falzoni, Michael F. Jarvis, Charles Kennedy, Baljit S. Khakh, Brian King, Patrizia Pellegatti, John A. Peters.
P2X receptors: P2X5. Last modified on 13/09/2018. Accessed on 16/09/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=482.
