nicotinic acetylcholine receptor α10 subunit | Nicotinic acetylcholine receptors | IUPHAR Guide to IMMUNOPHARMACOLOGY

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nicotinic acetylcholine receptor α10 subunit

Target not currently curated in GtoImmuPdb

Target id: 470

Nomenclature: nicotinic acetylcholine receptor α10 subunit

Family: Nicotinic acetylcholine receptors

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 450 11p15.5 CHRNA10 cholinergic receptor nicotinic alpha 10 subunit 2
Mouse 4 447 7 E3 Chrna10 cholinergic receptor, nicotinic, alpha polypeptide 10
Rat 4 447 1q32 Chrna10 cholinergic receptor nicotinic alpha 10 subunit 1
Previous and Unofficial Names
NACHR alpha 10 | nicotinic acetylcholine receptor subunit alpha 10 | cholinergic receptor, nicotinic, alpha 10 (neuronal) | cholinergic receptor, nicotinic alpha 10 | cholinergic receptor
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Functional Characteristics
α9α10: PCa/PNa = 9, Pf = 22%
Natural/Endogenous Ligands
Commonly used antagonists
α9α10: α-bungarotoxin > tropisetron = strychnine > tubocurarine

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
[3H]methyllycaconitine Hs Antagonist 8.1 pKd
pKd 8.1 (Kd 7.5x10-9 M) α9α10
RgIA4 Rn Antagonist 9.1 pIC50 3
pIC50 9.1 (IC50 9x10-10 M) α9α10 [3]
RgIA4 Hs Antagonist 8.8 pIC50 3
pIC50 8.8 (IC50 1.5x10-9 M) α9α10 [3]
strychnine Hs Antagonist - -
nicotine Hs Antagonist - -
α-bungarotoxin Hs Antagonist - -
muscarine Hs Antagonist - -
α-conotoxin RgIA Hs Antagonist - -
View species-specific antagonist tables
Tissue Distribution
Pituitary gland, keratinocytes
Species:  Human
Technique:  RT-PCR
References:  4
Pituitary gland (pars tuberalis region), cochlear, vestibular hair cells
Species:  Rat
Technique:  In situ hybridisation, RT-PCR
References:  1,4
Physiological Consequences of Altering Gene Expression
Knockout mice have abnormal innervation, synaptic function and morphology of the cochlear.
Species:  Mouse
Tissue:  in vivo
Technique:  Knockout
References:  5


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1. Elgoyhen AB, Vetter DE, Katz E, Rothlin CV, Heinemann SF, Boulter J. (2001) alpha10: a determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells. Proc. Natl. Acad. Sci. U.S.A., 98 (6): 3501-6. [PMID:11248107]

2. Lustig LR, Peng H, Hiel H, Yamamoto T, Fuchs PA. (2001) Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10). Genomics, 73 (3): 272-83. [PMID:11350119]

3. Romero HK, Christensen SB, Di Cesare Mannelli L, Gajewiak J, Ramachandra R, Elmslie KS, Vetter DE, Ghelardini C, Iadonato SP, Mercado JL et al.. (2017) Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain. Proc. Natl. Acad. Sci. U.S.A., 114 (10): E1825-E1832. [PMID:28223528]

4. Sgard F, Charpantier E, Bertrand S, Walker N, Caput D, Graham D, Bertrand D, Besnard F. (2002) A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit. Mol. Pharmacol., 61 (1): 150-9. [PMID:11752216]

5. Vetter DE, Katz E, Maison SF, Taranda J, Turcan S, Ballestero J, Liberman MC, Elgoyhen AB, Boulter J. (2007) The alpha10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system. Proc. Natl. Acad. Sci. U.S.A., 104 (51): 20594-9. [PMID:18077337]


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