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Target not currently curated in GtoImmuPdb
Target id: 466
Nomenclature: nicotinic acetylcholine receptor α5 subunit
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 4 | 468 | 15q25.1 | CHRNA5 | cholinergic receptor nicotinic alpha 5 subunit | 4 |
Mouse | 4 | 467 | 9 29.84 cM | Chrna5 | cholinergic receptor, nicotinic, alpha polypeptide 5 | 4 |
Rat | 4 | 452 | 8q24 | Chrna5 | cholinergic receptor nicotinic alpha 5 subunit | 2 |
Database Links ![]() |
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CATH/Gene3D | 2.70.170.10 |
ChEMBL Target | CHEMBL3137273 (Hs), CHEMBL3137272 (Hs), CHEMBL3038461 (Hs), CHEMBL3350222 (Mm), CHEMBL4106146 (Rn) |
Ensembl Gene | ENSG00000169684 (Hs), ENSMUSG00000035594 (Mm), ENSRNOG00000013610 (Rn) |
Entrez Gene | 1138 (Hs), 110835 (Mm), 25102 (Rn) |
Human Protein Atlas | ENSG00000169684 (Hs) |
KEGG Gene | hsa:1138 (Hs), mmu:110835 (Mm), rno:25102 (Rn) |
OMIM | 118505 (Hs) |
Pharos | P30532 (Hs) |
RefSeq Nucleotide | NM_000745 (Hs), NM_176844 (Mm), NM_017078 (Rn) |
RefSeq Protein | NP_000736 (Hs), NP_789814 (Mm), NP_058774 (Rn) |
UniProtKB | P30532 (Hs), Q2MKA5 (Mm), P20420 (Rn) |
Wikipedia | CHRNA5 (Hs) |
Natural/Endogenous Ligands ![]() |
acetylcholine |
Download all structure-activity data for this target as a CSV file
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Key to terms and symbols | View all chemical structures | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Tissue Distribution ![]() |
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Physiological Consequences of Altering Gene Expression ![]() |
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Clinically-Relevant Mutations and Pathophysiology ![]() |
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1. Bailey CD, De Biasi M, Fletcher PJ, Lambe EK. (2010) The nicotinic acetylcholine receptor alpha5 subunit plays a key role in attention circuitry and accuracy. J. Neurosci., 30 (27): 9241-52. [PMID:20610759]
2. Boulter J, O'Shea-Greenfield A, Duvoisin RM, Connolly JG, Wada E, Jensen A, Gardner PD, Ballivet M, Deneris ES, McKinnon D et al.. (1990) Alpha 3, alpha 5, and beta 4: three members of the rat neuronal nicotinic acetylcholine receptor-related gene family form a gene cluster. J. Biol. Chem., 265 (8): 4472-82. [PMID:1689727]
3. Brown RW, Collins AC, Lindstrom JM, Whiteaker P. (2007) Nicotinic alpha5 subunit deletion locally reduces high-affinity agonist activation without altering nicotinic receptor numbers. J. Neurochem., 103 (1): 204-15. [PMID:17573823]
4. Eng CM, Kozak CA, Beaudet AL, Zoghbi HY. (1991) Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse. Genomics, 9 (2): 278-82. [PMID:2004777]
5. Fischer H, Orr-Urtreger A, Role LW, Huck S. (2005) Selective deletion of the alpha5 subunit differentially affects somatic-dendritic versus axonally targeted nicotinic ACh receptors in mouse. J. Physiol. (Lond.), 563 (Pt 1): 119-37. [PMID:15611037]
6. Fowler CD, Lu Q, Johnson PM, Marks MJ, Kenny PJ. (2011) Habenular α5 nicotinic receptor subunit signalling controls nicotine intake. Nature, 471 (7340): 597-601. [PMID:21278726]
7. Hung RJ, McKay JD, Gaborieau V, Boffetta P, Hashibe M, Zaridze D, Mukeria A, Szeszenia-Dabrowska N, Lissowska J, Rudnai P et al.. (2008) A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature, 452 (7187): 633-7. [PMID:18385738]
8. Improgo MR, Scofield MD, Tapper AR, Gardner PD. (2010) The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer. Prog. Neurobiol., 92 (2): 212-26. [PMID:20685379]
9. Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI. (2010) Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J. Pharmacol. Exp. Ther., 334 (1): 137-46. [PMID:20400469]
10. Kuryatov A, Berrettini W, Lindstrom J. (2011) Acetylcholine receptor (AChR) α5 subunit variant associated with risk for nicotine dependence and lung cancer reduces (α4β2)₂α5 AChR function. Mol. Pharmacol., 79 (1): 119-25. [PMID:20881005]
11. Marks MJ, Pauly JR, Gross SD, Deneris ES, Hermans-Borgmeyer I, Heinemann SF, Collins AC. (1992) Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment. J. Neurosci., 12 (7): 2765-84. [PMID:1613557]
12. Saccone SF, Hinrichs AL, Saccone NL, Chase GA, Konvicka K, Madden PA, Breslau N, Johnson EO, Hatsukami D, Pomerleau O et al.. (2007) Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Hum. Mol. Genet., 16 (1): 36-49. [PMID:17135278]
13. Salas R, Orr-Urtreger A, Broide RS, Beaudet A, Paylor R, De Biasi M. (2003) The nicotinic acetylcholine receptor subunit alpha 5 mediates short-term effects of nicotine in vivo. Mol. Pharmacol., 63 (5): 1059-66. [PMID:12695534]
14. Wada E, McKinnon D, Heinemann S, Patrick J, Swanson LW. (1990) The distribution of mRNA encoded by a new member of the neuronal nicotinic acetylcholine receptor gene family (alpha 5) in the rat central nervous system. Brain Res., 526 (1): 45-53. [PMID:2078817]
15. Wang N, Orr-Urtreger A, Chapman J, Rabinowitz R, Korczyn AD. (2004) Nicotinic acetylcholine receptor alpha5 subunits modulate oxotremorine-induced salivation and tremor. J. Neurol. Sci., 222 (1-2): 87-91. [PMID:15240201]
16. Wang N, Orr-Urtreger A, Chapman J, Rabinowitz R, Nachman R, Korczyn AD. (2002) Autonomic function in mice lacking alpha5 neuronal nicotinic acetylcholine receptor subunit. J. Physiol. (Lond.), 542 (Pt 2): 347-54. [PMID:12122136]