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Target not currently curated in GtoImmuPdb
Target has curated data in GtoMPdb
Target id: 3174
Nomenclature: Plasmodium falciparum acetyl-CoA synthetase
Abbreviated Name: PfACS
Family: Other antimalarial targets
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Plasmodium falciparum 3D7 | - | 997 | ACAS | acetyl-CoA synthetase |
Previous and Unofficial Names |
ACAS | Pf3D7_06_v3:1,113,448..1,117,623(-) | PFF1350c | AcAS |
Database Links | |
Alphafold | C6KTB4 (Pf3D7) |
PlasmoDB | PF3D7_0627800 (Pf3D7) |
UniProtKB | C6KTB4 (Pf3D7) |
Whole Organism Assay Data Linked to This Target | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Malaria Pharmacology Comments |
P. falciparum acetyl-coenzyme A (CoA) synthetase (PfACS) has been selected by the Malaria Drug Accelerator (MalDA) consortium as a high priority target for antimalarial drug discovery [2]. The enzyme acetylates CoA to form acetyl CoA, an essential cellular metabolite. PfACS has been genetically and chemically validated [3,5]. |
1. de Vries LE, Jansen PAM, Barcelo C, Munro J, Verhoef JMJ, Pasaje CFA, Rubiano K, Striepen J, Bolscher JM, Henderson R et al.. (2021) Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183. bioRxiv, Preprint. DOI: 10.1101/2021.05.12.443866
2. Forte B, Ottilie S, Plater A, Campo B, Dechering KJ, Gamo FJ, Goldberg DE, Istvan ES, Lee M, Lukens AK et al.. (2021) Prioritization of Molecular Targets for Antimalarial Drug Discovery. ACS Infect Dis, 7 (10): 2764-2776. [PMID:34523908]
3. Schalkwijk J, Allman EL, Jansen PAM, de Vries LE, Verhoef JMJ, Jackowski S, Botman PNM, Beuckens-Schortinghuis CA, Koolen KMJ, Bolscher JM et al.. (2019) Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum. Sci Transl Med, 11 (510). [PMID:31534021]
4. Schalkwijk J, Hermkens PHH, Dechering KJ, Bonnert RV. (2020) Pantothenamide analogues. Patent number: WO2020141155A1. Assignee: Medicines for Malaria Venture (MMV). Priority date: 31/12/2018. Publication date: 09/07/2020.
5. Summers RL, Pasaje CFA, Pisco JP, Striepen J, Luth MR, Kumpornsin K, Carpenter EF, Munro JT, Lin D, Plater A et al.. (2022) Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention. Cell Chem Biol, 29 (2): 191-201.e8. [PMID:34348113]
Other antimalarial targets: Plasmodium falciparum acetyl-CoA synthetase. Last modified on 08/04/2022. Accessed on 06/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=3174.