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Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 7 | 1551 | 15q21.1 | DUOX1 | dual oxidase 1 | 1 |
Mouse | - | 1551 | Chromosome 2, 60.63 cM | Duox1 | dual oxidase 1 | |
Rat | 7 | 1551 | 3q35 | Duox1 | dual oxidase 1 |
Previous and Unofficial Names |
flavoprotein NADPH oxidase | LNOX1 | NADPH thyroid oxidase 1 | NOXEF1 | THOX1 |
Database Links | |
Alphafold | Q9NRD9 (Hs), Q8CIY2 (Rn) |
BRENDA | 1.6.3.1 |
Ensembl Gene | ENSG00000137857 (Hs), ENSMUSG00000033268 (Mm), ENSRNOG00000033348 (Rn) |
Entrez Gene | 53905 (Hs), 99439 (Mm), 266807 (Rn) |
Human Protein Atlas | ENSG00000137857 (Hs) |
KEGG Enzyme | 1.6.3.1 |
KEGG Gene | hsa:53905 (Hs), mmu:99439 (Mm), rno:266807 (Rn) |
OMIM | 606758 (Hs) |
Pharos | Q9NRD9 (Hs) |
RefSeq Nucleotide | NM_017434 (Hs), NM_001099297 (Mm), NM_153739 (Rn) |
RefSeq Protein | NP_059130 (Hs), NP_001092767 (Mm), NP_714961 (Rn) |
UniProtKB | Q9NRD9 (Hs), Q8CIY2 (Rn) |
Wikipedia | DUOX1 (Hs) |
Enzyme Reaction | ||||||||||
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Immunopharmacology Comments |
DUOX1 participates in innate immune responses to epithelial injury and allergens, and in the development of allergic diseases [7]. It is reported to play a role in mucous cell metaplasia and airway remodeling during allergic asthma [3]. |
Cell Type Associations | ||||||||
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Immuno Process Associations | ||
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Tissue Distribution | ||||||||
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1. De Deken X, Wang D, Many MC, Costagliola S, Libert F, Vassart G, Dumont JE, Miot F. (2000) Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family. J Biol Chem, 275 (30): 23227-33. [PMID:10806195]
2. Donkó A, Ruisanchez E, Orient A, Enyedi B, Kapui R, Péterfi Z, de Deken X, Benyó Z, Geiszt M. (2010) Urothelial cells produce hydrogen peroxide through the activation of Duox1. Free Radic Biol Med, 49 (12): 2040-8. [PMID:21146788]
3. Habibovic A, Hristova M, Heppner DE, Danyal K, Ather JL, Janssen-Heininger YM, Irvin CG, Poynter ME, Lundblad LK, Dixon AE et al.. (2016) DUOX1 mediates persistent epithelial EGFR activation, mucous cell metaplasia, and airway remodeling during allergic asthma. JCI Insight, 1 (18): e88811. [PMID:27812543]
4. Hirakawa S, Saito R, Ohara H, Okuyama R, Aiba S. (2011) Dual oxidase 1 induced by Th2 cytokines promotes STAT6 phosphorylation via oxidative inactivation of protein tyrosine phosphatase 1B in human epidermal keratinocytes. J Immunol, 186 (8): 4762-70. [PMID:21411736]
5. Kwon J, Shatynski KE, Chen H, Morand S, de Deken X, Miot F, Leto TL, Williams MS. (2010) The nonphagocytic NADPH oxidase Duox1 mediates a positive feedback loop during T cell receptor signaling. Sci Signal, 3 (133): ra59. [PMID:20682913]
6. Rada B, Park JJ, Sil P, Geiszt M, Leto TL. (2014) NLRP3 inflammasome activation and interleukin-1β release in macrophages require calcium but are independent of calcium-activated NADPH oxidases. Inflamm Res, 63 (10): 821-30. [PMID:25048991]
7. van der Vliet A, Danyal K, Heppner DE. (2018) Dual oxidase: a novel therapeutic target in allergic disease. Br J Pharmacol, 175 (9): 1401-1418. [PMID:29405261]