Glucokinase | Hexokinases | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 2798

Nomenclature: Glucokinase

Family: Hexokinases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 465 7p15.3-p15.1 GCK glucokinase
Mouse - 465 11 A1 Gck glucokinase
Rat - 498 14q21 Gck glucokinase
Gene and Protein Information Comments
In humans, the 465 amino acid form (isoform 1, NM_000162) is expressed specifically in pancreatic β cells. Isoforms 2 (466 amino acids, NM_NM_033507) and 3 (464 amino acids, NM_033508) are expressed in the liver, with isoform 2 being the predominant hepatic variant. The mouse expresses two isoforms; isoform 1 (465 amino acids, NM_010292) in pancreatic β cells and isoform 2 (465 amino acids, NM_001287386) in the liver.
Previous and Unofficial Names
glucokinase (hexokinase 4)
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
AZD1656 Hs Activation 7.2 pEC50 1
pEC50 7.2 (EC50 5.7x10-8 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Diabetes mellitus, noninsulin-dependent; NIDDM
Synonyms: Diabetes mellitus, Type II; T2D [OMIM: 125853]
Maturity onset diabetes
Type 2 diabetes mellitus [Disease Ontology: DOID:9352]
Disease Ontology: DOID:9352
OMIM: 125853
Disease:  Diabetes mellitus, permanent neonatal; PNDM
Synonyms: DEND syndrome [Orphanet: ORPHA79134]
Developmental delay-epilepsy-neonatal diabetes syndrome [Orphanet: ORPHA79134]
Permanent neonatal diabetes mellitus [Orphanet: ORPHA99885]
OMIM: 606176
Orphanet: ORPHA99885, ORPHA79134
Disease:  Hyperinsulinemic hypoglycemia, familial, 3; HHF3
Synonyms: Hyperinsulinemic hypoglycemia [Disease Ontology: DOID:13317]
Hyperinsulinism due to glucokinase deficiency [Orphanet: ORPHA79299]
Disease Ontology: DOID:13317
OMIM: 602485
Orphanet: ORPHA79299
Disease:  Maturity-onset diabetes of the young, type 2; MODY2
Synonyms: Maturity-onset diabetes of the young [Orphanet: ORPHA552] [OMIM: 606391] [Disease Ontology: DOID:0050524]
MODY [Orphanet: ORPHA552] [OMIM: 606391]
Disease Ontology: DOID:0050524
OMIM: 125851, 606391
Orphanet: ORPHA552


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1. AstraZeneca. AZD1656. Accessed on 17/09/2014. Modified on 17/09/2014.,

How to cite this page

Hexokinases: Glucokinase. Last modified on 15/04/2015. Accessed on 28/02/2020. IUPHAR/BPS Guide to PHARMACOLOGY,