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Target not currently curated in GtoImmuPdb

Target id: 2643

Nomenclature: tyrosinase

Family: 1.-.-.- Oxidoreductases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 529 11q14.3 TYR tyrosinase
Mouse 1 533 7 49.01 cM Tyr tyrosinase
Rat - 530 1q32 Tyr tyrosinase
Previous and Unofficial Names Click here for help
Database Links Click here for help
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number:

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 7 [PMID: 21334791] Small molecule or natural product ? Inhibition 6.4 pIC50 1
pIC50 6.4 (IC50 3.7x10-7 M) [1]
Immuno Process Associations
Immuno Process:  Immune system development
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Melanoma, cutaneous malignant, susceptibility to, 8; CMM8
OMIM: 601800
Disease:  Minimal pigment oculocutaneous albinism type 1
Orphanet: ORPHA352734
Disease:  Ocular albinism with congenital sensorineural deafness
OMIM: 103470
Orphanet: ORPHA352740
Disease:  Oculocutaneous albinism type 1A
Synonyms: Oculocutaneous albinism [Disease Ontology: DOID:0050632]
Disease Ontology: DOID:0050632
OMIM: 203100
Orphanet: ORPHA79431
Disease:  Oculocutaneous albinism type 1B
Synonyms: Oculocutaneous albinism [Disease Ontology: DOID:0050632]
Disease Ontology: DOID:0050632
OMIM: 606952
Orphanet: ORPHA79434
Disease:  Temperature-sensitive oculocutaneous albinism type 1
OMIM: 606952
Orphanet: ORPHA352737


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1. Tajima R, Oozeki H, Muraoka S, Tanaka S, Motegi Y, Nihei H, Yamada Y, Masuoka N, Nihei K. (2011) Synthesis and evaluation of bibenzyl glycosides as potent tyrosinase inhibitors. Eur J Med Chem, 46 (4): 1374-81. [PMID:21334791]

How to cite this page

1.-.-.- Oxidoreductases: tyrosinase. Last modified on 16/09/2015. Accessed on 21/02/2024. IUPHAR/BPS Guide to PHARMACOLOGY,