Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	393	12q24.31	HPD	4-hydroxyphenylpyruvate dioxygenase
Mouse	-	393	5 62.82 cM	Hpd	4-hydroxyphenylpyruvic acid dioxygenase
Rat	-	393	12q16	Hpd	4-hydroxyphenylpyruvate dioxygenase

Previous and Unofficial Names

4HPPD | GLOD3

Database Links
Alphafold	P32754 (Hs), P49429 (Mm), P32755 (Rn)
BRENDA	1.13.11.27
CATH/Gene3D	3.10.180.10
ChEMBL Target	CHEMBL1861 (Hs), CHEMBL5863 (Rn)
DrugBank Target	P32754 (Hs)
Ensembl Gene	ENSG00000158104 (Hs), ENSMUSG00000029445 (Mm), ENSRNOG00000001338 (Rn)
Entrez Gene	3242 (Hs), 15445 (Mm), 29531 (Rn)
Human Protein Atlas	ENSG00000158104 (Hs)
KEGG Enzyme	1.13.11.27
KEGG Gene	hsa:3242 (Hs), mmu:15445 (Mm), rno:29531 (Rn)
OMIM	609695 (Hs)
Orphanet	ORPHA122470 (Hs)
Pharos	P32754 (Hs)
RefSeq Nucleotide	NM_002150 (Hs), NM_008277 (Mm), NM_017233 (Rn)
RefSeq Protein	NP_002141 (Hs), NP_032303 (Mm), NP_058929 (Rn)
UniProtKB	P32754 (Hs), P49429 (Mm), P32755 (Rn)
Wikipedia	HPD (Hs)

Selected 3D Structures
	Description:  Crystal structure of human 4-Hydroxyphenylpyruvate dioxygenase PDB Id:  3ISQ Resolution:  1.75Å Species:  Human References:

Enzyme Reaction
EC Number: 1.13.11.27

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference nitisinone Pig Inhibition 7.4 pIC50 1 ⤷ pIC50 7.4 (IC50 4x10-8 M) [1]

Clinically-Relevant Mutations and Pathophysiology
Disease:  Hawkinsinuria OMIM: 140350 Orphanet: ORPHA2118
Disease:  Tyrosinemia, type III Disease Ontology: DOID:0050727 OMIM: 276710 Orphanet: ORPHA69723