alkaline ceramidase 3 | Alkaline ceramidases | IUPHAR Guide to IMMUNOPHARMACOLOGY

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alkaline ceramidase 3

  Target has curated data in GtoImmuPdb

Target id: 2470

Nomenclature: alkaline ceramidase 3

Family: Alkaline ceramidases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 267 11q13.5 ACER3 alkaline ceramidase 3
Mouse - 267 7 E2 Acer3 alkaline ceramidase 3
Rat - 267 1q32 Acer3 alkaline ceramidase 3
Previous and Unofficial Names
Alkaline CDase 3 | AlkCDase 3 | phytoceramidase, alkaline | Alkaline phytoceramidase
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number: 3.5.1.-
Immunopharmacology Comments
ACER3 may play a role in inflammation, since it is reported that loss of Acer3 in mice aggravates colitis and colitis-associated colorectal cancer [1]. This effect is thought to be the result of accumulation of the ACER3 substrate C18:1-ceramide, which potentiates LPS-induced production of pro-inflammatory cytokines in mouse immune cells.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0006954 inflammatory response IEA


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1. Wang K, Xu R, Snider AJ, Schrandt J, Li Y, Bialkowska AB, Li M, Zhou J, Hannun YA, Obeid LM et al.. (2016) Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system. Cell Death Dis, 7: e2124. [PMID:26938296]

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