Target has curated data in GtoImmuPdb
Contents:
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 7 | 267 | 11q13.5 | ACER3 | alkaline ceramidase 3 | |
| Mouse | 7 | 267 | 7 E1 | Acer3 | alkaline ceramidase 3 | |
| Rat | - | 267 | 1q32 | Acer3 | alkaline ceramidase 3 | |
| Previous and Unofficial Names |
| Alkaline CDase 3 | AlkCDase 3 | phytoceramidase, alkaline | Alkaline phytoceramidase |
| Database Links |
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| Alphafold | Q9NUN7 (Hs), Q9D099 (Mm) |
| BRENDA | 3.5.1.- |
| ChEMBL Target | CHEMBL4879509 (Mm) |
| Ensembl Gene | ENSG00000078124 (Hs), ENSMUSG00000030760 (Mm), ENSRNOG00000036866 (Rn) |
| Entrez Gene | 55331 (Hs), 66190 (Mm), 499210 (Rn) |
| Human Protein Atlas | ENSG00000078124 (Hs) |
| KEGG Enzyme | 3.5.1.- |
| KEGG Gene | hsa:55331 (Hs), mmu:66190 (Mm), rno:499210 (Rn) |
| Pharos | Q9NUN7 (Hs) |
| RefSeq Nucleotide | NM_018367 (Hs), NM_025408 (Mm), XM_001065019 (Rn), XM_574497 (Rn) |
| RefSeq Protein | NP_060837 (Hs), NP_079684 (Mm), XP_574497 (Rn), XP_001065019 (Rn) |
| UniProtKB | Q9NUN7 (Hs), Q9D099 (Mm) |
| Wikipedia | ACER3 (Hs) |
| Enzyme Reaction |
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| Immunopharmacology Comments |
| ACER3 may play a role in inflammation, since it is reported that loss of Acer3 in mice aggravates colitis and colitis-associated colorectal cancer [1]. This effect is thought to be the result of accumulation of the ACER3 substrate C18:1-ceramide, which potentiates LPS-induced production of pro-inflammatory cytokines in mouse immune cells. |
References
1. Wang K, Xu R, Snider AJ, Schrandt J, Li Y, Bialkowska AB, Li M, Zhou J, Hannun YA, Obeid LM et al.. (2016) Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system. Cell Death Dis, 7: e2124. [PMID:26938296]
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