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alkaline ceramidase 3

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 2470

Nomenclature: alkaline ceramidase 3

Family: Alkaline ceramidases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 267 11q13.5 ACER3 alkaline ceramidase 3
Mouse 7 267 7 E1 Acer3 alkaline ceramidase 3
Rat - 267 1q32 Acer3 alkaline ceramidase 3
Previous and Unofficial Names Click here for help
Alkaline CDase 3 | AlkCDase 3 | phytoceramidase, alkaline | Alkaline phytoceramidase
Database Links Click here for help
BRENDA
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.5.1.-
Immunopharmacology Comments
ACER3 may play a role in inflammation, since it is reported that loss of Acer3 in mice aggravates colitis and colitis-associated colorectal cancer [1]. This effect is thought to be the result of accumulation of the ACER3 substrate C18:1-ceramide, which potentiates LPS-induced production of pro-inflammatory cytokines in mouse immune cells.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0006954 inflammatory response IEA

References

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1. Wang K, Xu R, Snider AJ, Schrandt J, Li Y, Bialkowska AB, Li M, Zhou J, Hannun YA, Obeid LM et al.. (2016) Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system. Cell Death Dis, 7: e2124. [PMID:26938296]

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