integrin, alpha 4 subunit (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | Integrins | IUPHAR Guide to IMMUNOPHARMACOLOGY

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integrin, alpha 4 subunit (antigen CD49D, alpha 4 subunit of VLA-4 receptor)

  Target has curated data in GtoImmuPdb

Target id: 2443

Nomenclature: integrin, alpha 4 subunit (antigen CD49D, alpha 4 subunit of VLA-4 receptor)

Family: Integrins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Quaternary Structure: Complexes
integrin α4β1
integrin α4β7
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1032 2q31-q32 ITGA4 integrin subunit alpha 4
Mouse - 1039 2 C3 Itga4 integrin alpha 4
Rat - - 3q24 Itga4 integrin subunit alpha 4
Previous and Unofficial Names
CD49 antigen-like family member D | CD49D | integrin alpha-4 | lymphocyte Peyer patch adhesion molecules subunit alpha | integrin, alpha 4
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Parameter Reference
natalizumab Hs Inhibition - - 2
[2]
Antibody Comments
Natalizumab targets heteromeric integrin receptors of which α4 is a subunit.
Immunopharmacology Comments
Integrin subunit alpha 4 is the alpha subunit of the α4β1 lymphocyte homing receptor. The cytoplasmic domain of α4 binds tightly to paxillin, a signaling adaptor protein, and this interaction promotes increased cell migration and inhibits cell spreading [1]. Paxillin binding to α4 is blocked by phopshorylation of Ser988 in the α4 cytoplasmic tail.
α4-containing integrins are the molecular target of the monoclonal antibody natalizumab which was the first migration-inhibitory biological drug to be approved for inflammatory diseases.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 5 GO processes
GO:0050900 leukocyte migration TAS
GO:0050901 leukocyte tethering or rolling IMP
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GO:0050904 diapedesis IEA
GO:1903238 positive regulation of leukocyte tethering or rolling IEA
GO:2000406 positive regulation of T cell migration IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0030183 B cell differentiation IC
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes
GO:0050776 regulation of immune response TAS
click arrow to show/hide IEA associations
GO:1903238 positive regulation of leukocyte tethering or rolling IEA
GO:2000406 positive regulation of T cell migration IEA
Immuno Process:  Immune system development
GO Annotations:  Associated to 1 GO processes
GO:0030183 B cell differentiation IC
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 6 GO processes
GO:0007159 leukocyte cell-cell adhesion IDA
GO:0050900 leukocyte migration TAS
GO:0050901 leukocyte tethering or rolling IMP
click arrow to show/hide IEA associations
GO:0050904 diapedesis IEA
GO:1903238 positive regulation of leukocyte tethering or rolling IEA
GO:2000406 positive regulation of T cell migration IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0030183 B cell differentiation IC
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:1990771 clathrin-dependent extracellular exosome endocytosis IEA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0071345 cellular response to cytokine stimulus IEA

References

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1. Han J, Liu S, Rose DM, Schlaepfer DD, McDonald H, Ginsberg MH. (2001) Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding. J. Biol. Chem., 276 (44): 40903-9. [PMID:11533025]

2. No authors listed. (2004) Natalizumab: AN 100226, anti-4alpha integrin monoclonal antibody. Drugs R D, 5 (2): 102-7. [PMID:15293871]

How to cite this page

Integrins: integrin, alpha 4 subunit (antigen CD49D, alpha 4 subunit of VLA-4 receptor). Last modified on 19/04/2017. Accessed on 16/02/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2443.