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Target has curated data in GtoImmuPdb
Target id: 2443
Nomenclature: integrin, alpha 4 subunit (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
Family: Integrins
Quaternary Structure: Complexes |
integrin α4β1 |
integrin α4β7 |
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 1 | 1032 | 2q31.3 | ITGA4 | integrin subunit alpha 4 | |
Mouse | 1 | 1039 | 2 47.38 cM | Itga4 | integrin alpha 4 | |
Rat | - | - | 3q24 | Itga4 | integrin subunit alpha 4 |
Previous and Unofficial Names ![]() |
CD49 antigen-like family member D | CD49D | integrin alpha-4 | lymphocyte Peyer patch adhesion molecules subunit alpha | integrin, alpha 4 |
Database Links ![]() |
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ChEMBL Target | CHEMBL278 (Hs), CHEMBL2111481 (Mm) |
DrugBank Target | P13612 (Hs) |
Ensembl Gene | ENSG00000115232 (Hs), ENSMUSG00000027009 (Mm), ENSRNOG00000004861 (Rn) |
Entrez Gene | 3676 (Hs), 16401 (Mm), 311144 (Rn) |
Human Protein Atlas | ENSG00000115232 (Hs) |
KEGG Gene | hsa:3676 (Hs), mmu:16401 (Mm), rno:311144 (Rn) |
OMIM | 192975 (Hs) |
Pharos | P13612 (Hs) |
RefSeq Nucleotide | NM_000885 (Hs), NM_010576 (Mm) |
RefSeq Protein | NP_000876 (Hs), NP_034706 (Mm) |
UniProtKB | P13612 (Hs), Q00651 (Mm) |
Wikipedia | ITGA4 (Hs) |
Download all structure-activity data for this target as a CSV file
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Antibody Comments | |||||||||||||||||||||||||||||||||||||||||||||||||
Natalizumab targets heteromeric integrin receptors of which α4 is a subunit. |
Immunopharmacology Comments |
Integrin subunit alpha 4 is the alpha subunit of the α4β1 lymphocyte homing receptor. The cytoplasmic domain of α4 binds tightly to paxillin, a signaling adaptor protein, and this interaction promotes increased cell migration and inhibits cell spreading [1]. Paxillin binding to α4 is blocked by phopshorylation of Ser988 in the α4 cytoplasmic tail. α4-containing integrins are the molecular target of the monoclonal antibody natalizumab which was the first migration-inhibitory biological drug to be approved for inflammatory diseases. |
Immuno Process Associations | ||||||||||||
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1. Han J, Liu S, Rose DM, Schlaepfer DD, McDonald H, Ginsberg MH. (2001) Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding. J Biol Chem, 276 (44): 40903-9. [PMID:11533025]
2. No authors listed. (2004) Natalizumab: AN 100226, anti-4alpha integrin monoclonal antibody. Drugs R D, 5 (2): 102-7. [PMID:15293871]