Quaternary Structure: Complexes

integrin α4β1

integrin α4β7

Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	1032	2q31-q32	ITGA4	integrin subunit alpha 4
Mouse	-	1039	2 C3	Itga4	integrin alpha 4
Rat	-	-	3q24	Itga4	integrin subunit alpha 4

Previous and Unofficial Names

CD49 antigen-like family member D | CD49D | integrin alpha-4 | lymphocyte Peyer patch adhesion molecules subunit alpha | integrin, alpha 4

Database Links
ChEMBL Target	CHEMBL1907599 (Hs)
DrugBank Target	P13612 (Hs)
Ensembl Gene	ENSG00000115232 (Hs), ENSMUSG00000027009 (Mm), ENSRNOG00000004861 (Rn)
Entrez Gene	3676 (Hs), 16401 (Mm), 311144 (Rn)
Human Protein Atlas	ENSG00000115232 (Hs)
KEGG Gene	hsa:3676 (Hs), mmu:16401 (Mm), rno:311144 (Rn)
OMIM	192975 (Hs)
RefSeq Nucleotide	NM_000885 (Hs), NM_010576 (Mm)
RefSeq Protein	NP_000876 (Hs), NP_034706 (Mm)
UniProtKB	P13612 (Hs), Q00651 (Mm)
Wikipedia	ITGA4 (Hs)

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Antibodies
Key to terms and symbols		Click column headers to sort
Antibody Sp. Action Affinity Parameter Reference natalizumab Hs Inhibition - - 2 [2]
Antibody Comments
Natalizumab targets heteromeric integrin receptors of which α4 is a subunit.

Immunopharmacology Comments

Integrin subunit alpha 4 is the alpha subunit of the α4β1 lymphocyte homing receptor. The cytoplasmic domain of α4 binds tightly to paxillin, a signaling adaptor protein, and this interaction promotes increased cell migration and inhibits cell spreading [1]. Paxillin binding to α4 is blocked by phopshorylation of Ser988 in the α4 cytoplasmic tail. α4-containing integrins are the molecular target of the monoclonal antibody natalizumab which was the first migration-inhibitory biological drug to be approved for inflammatory diseases.

Immuno Process Associations

Immuno Process:  Inflammation GO Annotations:  Associated to 5 GO processes GO:0050900 leukocyte migration TAS GO:0050901 leukocyte tethering or rolling IMP click arrow to show/hide IEA associations GO:0050904 diapedesis IEA GO:1903238 positive regulation of leukocyte tethering or rolling IEA GO:2000406 positive regulation of T cell migration IEA

Immuno Process:  B cell (activation) GO Annotations:  Associated to 1 GO processes GO:0030183 B cell differentiation IC

Immuno Process:  Immune regulation GO Annotations:  Associated to 3 GO processes GO:0050776 regulation of immune response TAS click arrow to show/hide IEA associations GO:1903238 positive regulation of leukocyte tethering or rolling IEA GO:2000406 positive regulation of T cell migration IEA

Immuno Process:  Immune system development GO Annotations:  Associated to 1 GO processes GO:0030183 B cell differentiation IC

Immuno Process:  Chemotaxis & migration GO Annotations:  Associated to 6 GO processes GO:0007159 leukocyte cell-cell adhesion IDA GO:0050900 leukocyte migration TAS GO:0050901 leukocyte tethering or rolling IMP click arrow to show/hide IEA associations GO:0050904 diapedesis IEA GO:1903238 positive regulation of leukocyte tethering or rolling IEA GO:2000406 positive regulation of T cell migration IEA

Immuno Process:  Cellular signalling GO Annotations:  Associated to 1 GO processes GO:0030183 B cell differentiation IC

Immuno Process:  Antigen presentation GO Annotations:  Associated to 1 GO processes, IEA only click arrow to show/hide IEA associations GO:1990771 clathrin-dependent extracellular exosome endocytosis IEA

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 1 GO processes, IEA only click arrow to show/hide IEA associations GO:0071345 cellular response to cytokine stimulus IEA