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integrin, alpha 4 subunit (antigen CD49D, alpha 4 subunit of VLA-4 receptor)

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 2443

Nomenclature: integrin, alpha 4 subunit (antigen CD49D, alpha 4 subunit of VLA-4 receptor)

Family: Integrins

Quaternary Structure: Complexes
integrin α4β1
integrin α4β7
Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 1032 2q31.3 ITGA4 integrin subunit alpha 4
Mouse 1 1039 2 47.38 cM Itga4 integrin alpha 4
Rat - - 3q24 Itga4 integrin subunit alpha 4
Previous and Unofficial Names Click here for help
CD49 antigen-like family member D | CD49D | integrin alpha-4 | lymphocyte Peyer patch adhesion molecules subunit alpha | integrin, alpha 4
Database Links Click here for help
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

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Antibodies
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Antibody Sp. Action Value Parameter Reference
natalizumab Peptide Approved drug Primary target of this compound Click here for species-specific activity table Immunopharmacology Ligand Hs Inhibition - - 2
[2]
Antibody Comments
Natalizumab targets heteromeric integrin receptors of which α4 is a subunit.
Immunopharmacology Comments
Integrin subunit alpha 4 is the alpha subunit of the α4β1 lymphocyte homing receptor. The cytoplasmic domain of α4 binds tightly to paxillin, a signaling adaptor protein, and this interaction promotes increased cell migration and inhibits cell spreading [1]. Paxillin binding to α4 is blocked by phopshorylation of Ser988 in the α4 cytoplasmic tail.
α4-containing integrins are the molecular target of the monoclonal antibody natalizumab which was the first migration-inhibitory biological drug to be approved for inflammatory diseases.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 7 GO processes
GO:0002687 positive regulation of leukocyte migration ISO
GO:0050900 leukocyte migration TAS
GO:0050901 leukocyte tethering or rolling IMP
GO:0072678 T cell migration IMP
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GO:0050904 diapedesis IEA
GO:1903238 positive regulation of leukocyte tethering or rolling IEA
GO:2000406 positive regulation of T cell migration IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0030183 B cell differentiation IC
Immuno Process:  Immune regulation
GO Annotations:  Associated to 4 GO processes
GO:0002687 positive regulation of leukocyte migration ISO
GO:0050776 regulation of immune response TAS
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GO:1903238 positive regulation of leukocyte tethering or rolling IEA
GO:2000406 positive regulation of T cell migration IEA
Immuno Process:  Immune system development
GO Annotations:  Associated to 1 GO processes
GO:0030183 B cell differentiation IC
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 9 GO processes
GO:0002687 positive regulation of leukocyte migration ISO
GO:0007159 leukocyte cell-cell adhesion IDA
GO:0050900 leukocyte migration TAS
GO:0050901 leukocyte tethering or rolling IMP
GO:0072678 T cell migration IMP
GO:1903039 positive regulation of leukocyte cell-cell adhesion ISO
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GO:0050904 diapedesis IEA
GO:1903238 positive regulation of leukocyte tethering or rolling IEA
GO:2000406 positive regulation of T cell migration IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0030183 B cell differentiation IC
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:1990771 clathrin-dependent extracellular exosome endocytosis IEA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0071345 cellular response to cytokine stimulus IEA

References

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1. Han J, Liu S, Rose DM, Schlaepfer DD, McDonald H, Ginsberg MH. (2001) Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding. J Biol Chem, 276 (44): 40903-9. [PMID:11533025]

2. No authors listed. (2004) Natalizumab: AN 100226, anti-4alpha integrin monoclonal antibody. Drugs R D, 5 (2): 102-7. [PMID:15293871]

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