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Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 388 | 11q12.2 | PGA5 | pepsinogen A5 |
Previous and Unofficial Names |
Pepsin A-5 | pepsinogen 5, group I (pepsinogen A) |
Database Links | |
Specialist databases | |
MEROPS | A01.071 (Hs) |
Other databases | |
Alphafold | P0DJD9 (Hs) |
BRENDA | 3.4.23.1 |
CATH/Gene3D | 2.40.70.10 |
ChEMBL Target | CHEMBL3295 (Hs) |
Ensembl Gene | ENSG00000256713 (Hs) |
Entrez Gene | 5222 (Hs) |
Human Protein Atlas | ENSG00000256713 (Hs) |
KEGG Enzyme | 3.4.23.1 |
KEGG Gene | hsa:5222 (Hs) |
OMIM | 169730 (Hs) |
Pharos | P0DJD9 (Hs) |
RefSeq Nucleotide | NM_014224 (Hs) |
RefSeq Protein | NP_055039 (Hs) |
UniProtKB | P0DJD9 (Hs) |
Wikipedia | PGA5 (Hs) |
Enzyme Reaction | ||||
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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Inhibitor Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||
The approved drug sucralfate can inhibit pepsin enzymatic activity [1]. |
1. Furukawa O, Matsui H, Suzuki N. (1997) Effects of sucralfate and its components on acid- and pepsin-induced damage to rat gastric epithelial cells. Jpn J Pharmacol, 75 (1): 21-5. [PMID:9334882]
2. Rao CM, Scarborough PE, Kay J, Batley B, Rapundalo S, Klutchko S, Taylor MD, Lunney EA, Humblet CC, Dunn BM. (1993) Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation. J Med Chem, 36 (18): 2614-20. [PMID:8410973]
A1: Pepsin: pepsinogen A5. Last modified on 12/09/2019. Accessed on 10/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2390.